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The neuropeptide TR...
The neuropeptide TRH has a minor effect on the enzymatic activity of acetylcholinesterase in vitro.
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- Koskinen, Lars-Owe D., Professor, 1955- (author)
- Department of Biomedicine, Defense Research Establishment, Umeå, Sweden. Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden
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Koch, Mona L. (author)
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Puu, Gertrud (author)
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Department of Biomedicine, Defense Research Establishment, Umeå, Sweden Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden (creator_code:org_t)
- Elsevier BV, 1998
- 1998
- English.
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In: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 19:10, s. 1675-1677
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The neuropeptide thyrotropin-releasing hormone (TRH) elicits a variety of physiological effects of which some are due to cholinergic mechanisms. TRH modulates in vivo the effects of compounds affecting acetylcholinesterase (AChE). In the present study the in vitro effects of TRH on the activity of AChE were explored. TRH has no effect at physiologically relevant concentrations. At unphysiologically high concentrations (>5 mM) a slight inhibition was found. This was noticed also when the enzyme was exposed to the amide-free tripeptide analog p-Glu-His-Pro. We conclude that any cholinergic effect of TRH observed in vivo is unlikely to be due to a direct interaction of the peptide with AChE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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