Effects of age, sex and diet on salivary nitrate and nitrite in infants

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Timby, NiklasUmeå universitet,Pediatrik (author)

Effects of age, sex and diet on salivary nitrate and nitrite in infants

Article/chapterEnglish2020

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Elsevier,2020
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LIBRIS-ID:oai:DiVA.org:umu-168190
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168190URI
https://doi.org/10.1016/j.niox.2019.10.012DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:142851983URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The inorganic anions nitrate and nitrite are oxidation products from endogenous nitric oxide (NO) generation and constituents in our diet. A nitrate-nitrite-NO pathway exists in which nitrate can be serially reduced to bioactive NO. The first step of this pathway occurs in the oral cavity where oral bacteria convert salivary nitrate to nitrite, whereafter nitrite is reduced to NO systemically by several enzymatic and non-enzymatic pathways. Data are scarce regarding salivary levels and oral conversion capacity of these anions in infants. We measured salivary nitrate and nitrate in infants at 4 and 12 months of age and related values to age, sex, dietary pattern and oral microbiome. Saliva was collected from a total of 188 infants at 4 and 12 months of age. Salivary nitrate, nitrite and nitrite/nitrate ratio as a measure of oral nitrate-reducing capacity were analyzed by HPLC and related to age, sex, type of diet (breast milk or formula) and oral microbiome. There was no difference in salivary nitrate, nitrite or nitrite/nitrate ratio between boys and girls at any age. At 4 months levels of these parameters were lower than what has been described in adults but they had all increased significantly at 12 months of age. At 4 months of age salivary nitrite/nitrate ratio was lower in breast-fed compared to formula-fed infants, but these differences disappeared at 12 months. Several bacterial species were associated with oral nitrate reducing capacity including Prevotella, Veillonella, Alloprevotella and Leptotrichia. We conclude that in infants there is an increase in salivary nitrate and nitrite as well as in oral nitrate-reductase capacity during the first year of life. Differences observed at 4 months of age between breast-fed and formula-fed infants disappear at one year of age.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Oral
Saliva
Bacteria
Nitric oxide
Nutrition
Formula

Added entries (persons, corporate bodies, meetings, titles ...)

Domellöf, Magnus,1963-Umeå universitet,Pediatrik(Swepub:umu)mado0002 (author)
Hernell, OlleUmeå universitet,Pediatrik(Swepub:umu)olhe0002 (author)
Lönnerdal, Bo (author)
Nihlen, CarinaKarolinska Institutet (author)
Johansson, IngegerdUmeå universitet,Institutionen för odontologi(Swepub:umu)injo0003 (author)
Weitzberg, EddieKarolinska Institutet (author)
Hernell, E (author)
Umeå universitetPediatrik (creator_code:org_t)

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In:Nitric oxide: Elsevier94, s. 73-781089-86031089-8611

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By the author/editor: Timby, Niklas; Domellöf, Magnus ...; Hernell, Olle; Lönnerdal, Bo; Nihlen, Carina; Johansson, Ingeg ...; show more...; Weitzberg, Eddie; Hernell, E; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

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