Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity.

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McWhinney, Sean R (author)

Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity.

Article/chapterEnglish2024

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2024

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LIBRIS-ID:oai:gup.ub.gu.se/338949
https://gup.ub.gu.se/publication/338949URI
https://doi.org/10.1002/hbm.26682DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:158414620URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather by variations across distributed brain networks. Here, we used principal component analysis (PCA) to identify patterns of covariance across brain regions and relate them to clinical and demographic variables in a large generalizable dataset of individuals with bipolar disorders and controls. We then compared performance of PCA and clustering on identical sample to identify which methodology was better in capturing links between brain and clinical measures. Using data from the ENIGMA-BD working group, we investigated T1-weighted structural MRI data from 2436 participants with BD and healthy controls, and applied PCA to cortical thickness and surface area measures. We then studied the association of principal components with clinical and demographic variables using mixed regression models. We compared the PCA model with our prior clustering analyses of the same data and also tested it in a replication sample of 327 participants with BD or schizophrenia and healthy controls. The first principal component, which indexed a greater cortical thickness across all 68 cortical regions, was negatively associated with BD, BMI, antipsychotic medications, and age and was positively associated with Li treatment. PCA demonstrated superior goodness of fit to clustering when predicting diagnosis and BMI. Moreover, applying the PCA model to the replication sample yielded significant differences in cortical thickness between healthy controls and individuals with BD or schizophrenia. Cortical thickness in the same widespread regional network as determined by PCA was negatively associated with different clinical and demographic variables, including diagnosis, age, BMI, and treatment with antipsychotic medications or lithium. PCA outperformed clustering and provided an easy-to-use and interpret method to study multivariate associations between brain structure and system-level variables. PRACTITIONER POINTS: In this study of 2770 Individuals, we confirmed that cortical thickness in widespread regional networks as determined by principal component analysis (PCA) was negatively associated with relevant clinical and demographic variables, including diagnosis, age, BMI, and treatment with antipsychotic medications or lithium. Significant associations of many different system-level variables with the same brain network suggest a lack of one-to-one mapping of individual clinical and demographic factors to specific patterns of brain changes. PCA outperformed clustering analysis in the same data set when predicting group or BMI, providing a superior method for studying multivariate associations between brain structure and system-level variables.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Humans
Bipolar Disorder
diagnostic imaging
drug therapy
pathology
Principal Component Analysis
Adult
Female
Male
Magnetic Resonance Imaging
methods
Middle Aged
Obesity
diagnostic imaging
Schizophrenia
diagnostic imaging
pathology
drug therapy
physiopathology
Cerebral Cortex
diagnostic imaging
pathology
Cluster Analysis
Young Adult
Brain
diagnostic imaging
pathology

Added entries (persons, corporate bodies, meetings, titles ...)

Hlinka, Jaroslav (author)
Bakstein, Eduard (author)
Dietze, Lorielle M F (author)
Corkum, Emily L V (author)
Abé, Christoph (author)
Alda, Martin (author)
Alexander, Nina (author)
Benedetti, Francesco (author)
Berk, Michael (author)
Bøen, Erlend (author)
Bonnekoh, Linda M (author)
Boye, Birgitte (author)
Brosch, Katharina (author)
Canales-Rodríguez, Erick J (author)
Cannon, Dara M (author)
Dannlowski, Udo (author)
Demro, Caroline (author)
Diaz-Zuluaga, Ana (author)
Elvsåshagen, Torbjørn (author)
Eyler, Lisa T (author)
Fortea, Lydia (author)
Fullerton, Janice M (author)
Goltermann, Janik (author)
Gotlib, Ian H (author)
Grotegerd, Dominik (author)
Haarman, Bartholomeus (author)
Hahn, Tim (author)
Howells, Fleur M (author)
Jamalabadi, Hamidreza (author)
Jansen, Andreas (author)
Kircher, Tilo (author)
Klahn, LuisaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xklalu (author)
Kuplicki, Rayus (author)
Lahud, Elijah (author)
Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
Leehr, Elisabeth J (author)
Lopez-Jaramillo, Carlos (author)
Mackey, Scott (author)
Malt, Ulrik (author)
Martyn, Fiona (author)
Mazza, Elena (author)
McDonald, Colm (author)
McPhilemy, Genevieve (author)
Meier, Sandra (author)
Meinert, Susanne (author)
Melloni, Elisa (author)
Mitchell, Philip B (author)
Nabulsi, Leila (author)
Nenadić, Igor (author)
Nitsch, Robert (author)
Opel, Nils (author)
Ophoff, Roel A (author)
Ortuño, Maria (author)
Overs, Bronwyn J (author)
Pineda-Zapata, Julian (author)
Pomarol-Clotet, Edith (author)
Radua, Joaquim (author)
Repple, Jonathan (author)
Roberts, Gloria (author)
Rodriguez-Cano, Elena (author)
Sacchet, Matthew D (author)
Salvador, Raymond (author)
Savitz, Jonathan (author)
Scheffler, Freda (author)
Schofield, Peter R (author)
Schürmeyer, Navid (author)
Shen, Chen (author)
Sim, Kang (author)
Sponheim, Scott R (author)
Stein, Dan J (author)
Stein, Frederike (author)
Straube, Benjamin (author)
Suo, Chao (author)
Temmingh, Henk (author)
Teutenberg, Lea (author)
Thomas-Odenthal, Florian (author)
Thomopoulos, Sophia I (author)
Urosevic, Snezana (author)
Usemann, Paula (author)
van Haren, Neeltje E M (author)
Vargas, Cristian (author)
Vieta, Eduard (author)
Vilajosana, Enric (author)
Vreeker, Annabel (author)
Winter, Nils R (author)
Yatham, Lakshmi N (author)
Thompson, Paul M (author)
Andreassen, Ole A (author)
Ching, Christopher R K (author)
Hajek, Tomas (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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By the author/editor: McWhinney, Sean ...; Hlinka, Jaroslav; Bakstein, Eduard; Dietze, Lorielle ...; Corkum, Emily L ...; Abé, Christoph; show more...; Alda, Martin; Alexander, Nina; Benedetti, Franc ...; Berk, Michael; Bøen, Erlend; Bonnekoh, Linda ...; Boye, Birgitte; Brosch, Katharin ...; Canales-Rodrígue ...; Cannon, Dara M; Dannlowski, Udo; Demro, Caroline; Diaz-Zuluaga, An ...; Elvsåshagen, Tor ...; Eyler, Lisa T; Fortea, Lydia; Fullerton, Janic ...; Goltermann, Jani ...; Gotlib, Ian H; Grotegerd, Domin ...; Haarman, Barthol ...; Hahn, Tim; Howells, Fleur M; Jamalabadi, Hami ...; Jansen, Andreas; Kircher, Tilo; Klahn, Luisa; Kuplicki, Rayus; Lahud, Elijah; Landén, Mikael, ...; Leehr, Elisabeth ...; Lopez-Jaramillo, ...; Mackey, Scott; Malt, Ulrik; Martyn, Fiona; Mazza, Elena; McDonald, Colm; McPhilemy, Genev ...; Meier, Sandra; Meinert, Susanne; Melloni, Elisa; Mitchell, Philip ...; Nabulsi, Leila; Nenadić, Igor; Nitsch, Robert; Opel, Nils; Ophoff, Roel A; Ortuño, Maria; Overs, Bronwyn J; Pineda-Zapata, J ...; Pomarol-Clotet, ...; Radua, Joaquim; Repple, Jonathan; Roberts, Gloria; Rodriguez-Cano, ...; Sacchet, Matthew ...; Salvador, Raymon ...; Savitz, Jonathan; Scheffler, Freda; Schofield, Peter ...; Schürmeyer, Navi ...; Shen, Chen; Sim, Kang; Sponheim, Scott ...; Stein, Dan J; Stein, Frederike; Straube, Benjami ...; Suo, Chao; Temmingh, Henk; Teutenberg, Lea; Thomas-Odenthal, ...; Thomopoulos, Sop ...; Urosevic, Snezan ...; Usemann, Paula; van Haren, Neelt ...; Vargas, Cristian; Vieta, Eduard; Vilajosana, Enri ...; Vreeker, Annabel; Winter, Nils R; Yatham, Lakshmi ...; Thompson, Paul M; Andreassen, Ole ...; Ching, Christoph ...; Hajek, Tomas; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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