Sökning: (WFRF:(Palmqvist Richard)) pers:(Edin Sofia) >
The Prognostic Impo...
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Edin, SofiaUmeå universitet,Patologi
(författare)
The Prognostic Importance of CD20+ B lymphocytes in Colorectal Cancer and the Relation to Other Immune Cell subsets
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-12-27
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Nature Publishing Group,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-168708
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168708URI
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https://doi.org/10.1038/s41598-019-56441-8DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168173URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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The work was also supported by the Sigrid Jusélius Foundation, the Finnish Cancer Foundation, and the Nordic Cancer Union.
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The anti-tumour immune response is critical to patient prognosis in colorectal cancer (CRC). The aim of this study was to investigate infiltration of B lymphocytes into CRC tumours, and their clinical relevance, prognostic value and relation to other immune cell subsets. We used multiplexed immunohistochemistry and multispectral imaging to assay the amount of infiltrating CD20+ B lymphocytes along with infiltration of CD8+ cytotoxic T cells, FOXP3+ T regulatory cells, CD68+ macrophages and CD66b+ neutrophils, in 316 archival CRC tissue specimens. A higher density of infiltrating CD20+ B lymphocytes was associated with tumours of the right colon (P = 0.025) and of lower stages (P = 0.009). Furthermore, patients whose tumours were highly infiltrated by CD20+ B lymphocytes had a significantly improved disease-specific survival (HR = 0.45, 95% CI 0.28-0.73, P = 0.001), which remained significant in multivariable analysis. CD20+ B lymphocytes were highly and positively associated with CD8+ T lymphocytes (P < 0.001), and part of the prognostic role was found to be a cooperative effect between these lymphocyte subsets. Our results support a favourable prognostic value of tumour-infiltrating CD20+ B lymphocytes in CRC. Furthermore, a cooperative prognostic effect between CD20+ B lymphocytes and CD8+ T lymphocytes is suggested.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kaprio, TuomasDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
(författare)
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Hagström, JaanaTranslational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
(författare)
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Larsson, PärUmeå universitet,Patologi,Klinisk bakteriologi,Medicinsk och klinisk genetik(Swepub:umu)pala0006
(författare)
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Mustonen, HarriDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
(författare)
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Böckelman, CamillaDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
(författare)
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Strigård, KarinUmeå universitet,Kirurgi,Clister(Swepub:umu)kast0065
(författare)
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Gunnarsson, UlfUmeå universitet,Kirurgi,Clister(Swepub:umu)ulgu0014
(författare)
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Haglund, CajDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
(författare)
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Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001
(författare)
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Umeå universitetPatologi
(creator_code:org_t)
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Ingår i:Scientific Reports: Nature Publishing Group9:12045-2322
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Edin, Sofia
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Kaprio, Tuomas
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Hagström, Jaana
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Larsson, Pär
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Mustonen, Harri
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Böckelman, Camil ...
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Strigård, Karin
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Gunnarsson, Ulf
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Haglund, Caj
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