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Multicenter prospec...
Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004-2005 : the REVEAL study.
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Van Damme, Pierre (author)
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Giaquinto, Carlo (author)
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Huet, Frederic (author)
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- Gothefors, Leif (author)
- Umeå universitet,Pediatrik
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Maxwell, Melanie (author)
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Van der Wielen, Marie (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: J Infect Dis. - 0022-1899. ; 195 Suppl 1, s. S4-S16
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Rotavirus is recognized as a significant cause of pediatric gastroenteritis worldwide. Comprehensive data on the burden of rotavirus disease in Europe were lacking. METHODS: A prospective, multicenter, observational study was conducted during the 2004-2005 season in selected areas of Belgium, France, Germany, Italy, Spain, Sweden, and the United Kingdom, to estimate the incidence of acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) in children <5 years of age who require medical care in primary care, emergency department, and hospital settings. RESULTS: A total of 2846 children with AGE were included in the study, and, of the 2712 children for whom ELISA results were available, 1102 (40.6%) were found to be rotavirus positive. The estimated annual incidence of RVGE was 2.07-4.97 cases/100 children <5 years of age, and it was highest among children 6-23 months of age, with 56.7%-74.2% of all RVGE cases occurring in children in this age group. Overall, RVGE was estimated to account for 27.8%-52.0% of AGE cases, and it was responsible for up to two-thirds of hospitalizations and emergency department consultations, as well as one-third of primary care consultations for AGE. CONCLUSIONS: Rotavirus infections account for a significant proportion of AGE cases in children <5 years of age in Europe, many of whom require frequent primary care consultations or care in emergency department and/or hospital settings. The results of the present study suggest that routine rotavirus vaccination for infants <6 months of age could significantly reduce the substantial burden of this potentially serious childhood disease.
Keyword
- Rotavirus
- gastroenteritis
Publication and Content Type
- ref (subject category)
- art (subject category)
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