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  • Backman, HelenaLuleå tekniska universitet,Umeå universitet,Avdelningen för hållbar hälsa,Avdelningen för medicin,Dept of Health Sciences, Luleå University of Technology, Luleå, Sweden.,Dept of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden,Omvårdnad och medicinsk teknik (author)

FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-169223
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169223URI
  • https://doi.org/10.1016/j.waojou.2020.100110DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-78305URI
  • https://gup.ub.gu.se/publication/294418URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Validerad;2020;Nivå 2;2020-04-03 (alebob)
  • Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies.Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a population-based adult asthma cohort.Methods: In 2012-2014, an adult asthma cohort was invited to a follow-up including spirometry, blood sampling, and structured interviews, and n = 892 participated (55% women, mean age 59 y, 32-92 y). Blood eosinophils, neutrophils and FEV 1 decline were analyzed both as continuous variables and divided into categories with different cut-offs. Regression models adjusted for smoking, exposure to vapors, gas, dust, or fumes (VGDF), use of inhaled and oral corticosteroids, and other possible confounders were utilized to analyze the relationship between eosinophils and neutrophils at follow-up and FEV1 decline.Results: The mean follow-up time was 18 years, and the mean FEV 1 decline was 27 ml/year. The annual FEV1 decline was related to higher levels of both blood eosinophils and neutrophils at follow-up, but only the association with eosinophils remained when adjusted for confounders. Further, the association between FEV1 decline and eosinophils was stronger among those using ICS. With EOS <0.3 × 109/L as reference, a more rapid decline in FEV1 was independently related to EOS ≥0.4 × 109/L in adjusted analyses.Conclusions and clinical relevance: Besides emphasizing the importance of smoking cessation and reduction of other harmful exposures, our real-world results indicate that there is an independent relationship between blood eosinophils and FEV1 decline among adults with asthma.

Subject headings and genre

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  • Lindberg, AnneUmeå universitet,Avdelningen för medicin,Dept of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden(Swepub:umu)anelig02 (author)
  • Hedman, Linnea,1979-Luleå tekniska universitet,Umeå universitet,Avdelningen för hållbar hälsa,Dept of Health Sciences, Luleå University of Technology, Luleå, Sweden.,Dept of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden,Omvårdnad och medicinsk teknik(Swepub:ltu)linhed (author)
  • Stridsman, CarolineLuleå tekniska universitet,Umeå universitet,Avdelningen för medicin,Dept of Health Sciences, Luleå University of Technology, Luleå, Sweden.,Omvårdnad och medicinsk teknik,Dept of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden(Swepub:ltu)carstr (author)
  • Jansson, Sven-ArneUmeå universitet,Avdelningen för hållbar hälsa,Dept of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden(Swepub:umu)svja0005 (author)
  • Sandström, Thomas,1957-Umeå universitet,Avdelningen för medicin,Dept of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden(Swepub:umu)thsa0001 (author)
  • Lundbäck, Bo,1948Gothenburg University,Göteborgs universitet,Umeå universitet,Avdelningen för hållbar hälsa,Dept of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden. Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden,Krefting Research Centre(Swepub:gu)xlunbo (author)
  • Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa,Dept of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden(Swepub:umu)evra0004 (author)
  • Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

Related titles

  • In:World Allergy Organization Journal: Elsevier13:31939-4551

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