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  • Bos, Maxime M. (författare)

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-03-02
  • Springer,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-169440
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169440URI
  • https://doi.org/10.1007/s11306-020-01653-7DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Several plasma metabolites have been associated with insulin resistance and type 2 diabetes mellitus.Objectives: We aimed to identify plasma metabolites associated with different indices of early disturbances in glucose metabolism and insulin sensitivity.Methods: This cross-sectional study was conducted in a subsample of the Leiden Longevity Study comprising individuals without a history of diabetes mellitus (n = 233) with a mean age of 63.3 ± 6.7 years of which 48.1% were men. We tested for associations of fasting glucose, fasting insulin, HOMA-IR, Matsuda Index, Insulinogenic Index and glycated hemoglobin with metabolites (Swedish Metabolomics Platform) using linear regression analysis adjusted for age, sex and BMI. Results were validated internally using an independent metabolomics platform (Biocrates platform) and replicated externally in the independent Netherlands Epidemiology of Obesity (NEO) study (Metabolon platform) (n = 545, mean age of 55.8 ± 6.0 years of which 48.6% were men). Moreover, in the NEO study, we replicated our analyses in individuals with diabetes mellitus (cases: n = 36; controls = 561).Results: Out of the 34 metabolites, a total of 12 plasma metabolites were associated with different indices of disturbances in glucose metabolism and insulin sensitivity in individuals without diabetes mellitus. These findings were validated using a different metabolomics platform as well as in an independent cohort of non-diabetics. Moreover, tyrosine, alanine, valine, tryptophan and alpha-ketoglutaric acid levels were higher in individuals with diabetes mellitus.Conclusion: We found several plasma metabolites that are associated with early disturbances in glucose metabolism and insulin sensitivity of which five were also higher in individuals with diabetes mellitus.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Noordam, Raymond (författare)
  • Bennett, Kate (författare)
  • Beekman, Marian (författare)
  • Mook-Kanamori, Dennis O. (författare)
  • van Dijk, Ko (författare)
  • Slagboom, P. Eline (författare)
  • Lundstedt, Torbjorn (författare)
  • Surowiec, IzabellaUmeå universitet,Kemiska institutionen,AcureOmics AB, Umeå, Sweden(Swepub:umu)izsu0001 (författare)
  • van Heemst, Diana (författare)
  • Umeå universitetKemiska institutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Metabolomics: Springer16:31573-38821573-3890

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