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- Martin, Oceane C. B. (author)
Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-01-21
- MDPI,2020
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-169743
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169743URI
- https://doi.org/10.3390/toxins12020063DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:143252288URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative bacteria, the typhoid toxin produced by several Salmonella enterica serovars, and colibactin, a peptide-polyketide, produced mainly by the phylogenetic group B2 Escherichia coli. The cellular responses induced by BTGXs resemble those of well-characterized carcinogenic agents, and several lines of evidence indicate that bacteria carrying genotoxin genes can contribute to tumor development under specific circumstances. Given their unusual mode of action, it is still enigmatic why these effectors have been acquired by microbes and what is their role in the context of the biology of the producing bacterium, since it is unlikely that their primary purpose is to induce/promote cancer in the mammalian host. In this review, we will discuss the possibility that the DNA damage induced by BTGX modulates the host immune response, acting as immunomodulator, leading to the establishment of a suitable niche for the producing bacterium. We will further highlight open questions that remain to be solved regarding the biology of this unusual family of bacterial toxins.
Subject headings and genre
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- bacterial genotoxins
- DNA damage
- DNA damage response
- immune response
- immunomodulation
- senescence
Added entries (persons, corporate bodies, meetings, titles ...)
- Frisan, Teresa,1967-Karolinska Institutet,Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Umeå Centre for Microbial Research (UCMR),Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden(Swepub:umu)tefr0009 (author)
- Umeå universitetInstitutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet) (creator_code:org_t)
Related titles
- In:Toxins: MDPI12:22072-6651
Internet link
- https://doi.org/10.3390/toxins12020063Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1430038/FULLTEXT01.pdffulltext:print
- https://www.mdpi.com/2072-6651/12/2/63/pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169743
- https://doi.org/10.3390/toxins12020063
- http://kipublications.ki.se/Default.aspx?queryparsed=id:143252288
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