Search: (WFRF:(Vodicka Pavel)) srt2:(2020-2021) >
Identification of N...
Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians
-
Lu, Yingchang (author)
-
Kweon, Sun-Seog (author)
-
Cai, Qiuyin (author)
-
show more...
-
Tanikawa, Chizu (author)
-
Shu, Xiao-Ou (author)
-
Jia, Wei-Hua (author)
-
Xiang, Yong-Bing (author)
-
Huyghe, Jeroen R. (author)
-
Harrison, Tabitha A. (author)
-
Kim, Jeongseon (author)
-
Shin, Aesun (author)
-
Kim, Dong-Hyun (author)
-
Matsuo, Keitaro (author)
-
Jee, Sun Ha (author)
-
Guo, Xingyi (author)
-
Wen, Wanqing (author)
-
Shi, Jiajun (author)
-
Li, Bingshan (author)
-
Wang, Nan (author)
-
Shin, Min-Ho (author)
-
Li, Hong-Lan (author)
-
Ren, Zefang (author)
-
Oh, Jae Hwan (author)
-
Oze, Isao (author)
-
Ahn, Yoon-Ok (author)
-
Jung, Keum Ji (author)
-
Gao, Jing (author)
-
Gao, Yu-Tang (author)
-
Pan, Zhi-Zhong (author)
-
Kamatani, Yoichiro (author)
-
Chan, Andrew T. (author)
-
Gsur, Andrea (author)
-
Hampe, Jochen (author)
-
Le Marchand, Loic (author)
-
Li, Li (author)
-
- Lindblom, Annika (author)
- Karolinska Institutet
-
Moreno, Victor (author)
-
Newcomb, Polly A. (author)
-
Offit, Kenneth (author)
-
Pharoah, Paul D. P. (author)
-
Van Duijnhoven, Franzel J. B. (author)
-
- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
-
Vodicka, Pavel (author)
-
Weinstein, Stephanie J. (author)
-
- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi
-
Wu, Anna H. (author)
-
Hsu, Li (author)
-
Zeng, Yi-Xin (author)
-
Long, Jirong (author)
-
Peters, Ulrike (author)
-
Matsuda, Koichi (author)
-
Zheng, Wei (author)
-
show less...
-
(creator_code:org_t)
- American Association for Cancer Research, 2020
- 2020
- English.
-
In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 29:2, s. 477-486
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: Risk variants identified so far for colorectal cancer explain only a small proportion of milial risk of this cancer, particularly in Asians.Methods: We performed a genome-wide association study (GWAS) of colorectal cancer in East Asians, cluding 23,572 colorectal cancer cases and 48,700 controls. To identify novel risk loci, we selected 60 omising risk variants for replication using data from 58,131 colorectal cancer cases and 67,347 controls European descent. To identify additional risk variants in known colorectal cancer loci, we performed nditional analyses in East Asians.Results: An indel variant, rs67052019 at 1p13.3, was found to be associated with colorectal cancer risk P = 3.9 x 10(-8) in Asians (OR per allele deletion = 1.13, 95% confidence interval = 1.08-1.18). This sociation was replicated in European descendants using a variant (rs2938616) in complete linkage sequilibrium with rs67052019 (P = 7.7 x 10(-3)). Of the remaining 59 variants, 12 showed an association P < 0.05 in the European-ancestry study, including rs11108175 and rs9634162 at P < 5 x 10(-8) and o variants with an association near the genome-wide significance level (rs60911071, P = 5.8 x 10(-8); 62558833, P = 7.5 x 10(-8)) in the combined analyses of Asian- and European-ancestry data. In addition, ing data from East Asians, we identified 13 new risk variants at 11 loci reported from previous GWAS.Conclusions: In this large GWAS, we identified three novel risk loci and two highly suggestive loci for lorectal cancer risk and provided evidence for potential roles of multiple genes and pathways in the iology of colorectal cancer. In addition, we showed that additional risk variants exist in many colorectal ncer risk loci identified previously.Impact: Our study provides novel data to improve the understanding of the genetic basis for colorectal ncer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lu, Yingchang
-
Kweon, Sun-Seog
-
Cai, Qiuyin
-
Tanikawa, Chizu
-
Shu, Xiao-Ou
-
Jia, Wei-Hua
-
show more...
-
Xiang, Yong-Bing
-
Huyghe, Jeroen R ...
-
Harrison, Tabith ...
-
Kim, Jeongseon
-
Shin, Aesun
-
Kim, Dong-Hyun
-
Matsuo, Keitaro
-
Jee, Sun Ha
-
Guo, Xingyi
-
Wen, Wanqing
-
Shi, Jiajun
-
Li, Bingshan
-
Wang, Nan
-
Shin, Min-Ho
-
Li, Hong-Lan
-
Ren, Zefang
-
Oh, Jae Hwan
-
Oze, Isao
-
Ahn, Yoon-Ok
-
Jung, Keum Ji
-
Gao, Jing
-
Gao, Yu-Tang
-
Pan, Zhi-Zhong
-
Kamatani, Yoichi ...
-
Chan, Andrew T.
-
Gsur, Andrea
-
Hampe, Jochen
-
Le Marchand, Loi ...
-
Li, Li
-
Lindblom, Annika
-
Moreno, Victor
-
Newcomb, Polly A ...
-
Offit, Kenneth
-
Pharoah, Paul D. ...
-
Van Duijnhoven, ...
-
van Guelpen, Bet ...
-
Vodicka, Pavel
-
Weinstein, Steph ...
-
Wolk, Alicja
-
Wu, Anna H.
-
Hsu, Li
-
Zeng, Yi-Xin
-
Long, Jirong
-
Peters, Ulrike
-
Matsuda, Koichi
-
Zheng, Wei
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Cancer Epidemiol ...
- By the university
-
Umeå University
-
Uppsala University
-
Karolinska Institutet