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Interleukin-1 recep...
Interleukin-1 receptor antagonist is associated with both lipid metabolism and inflammation in rheumatoid arthritis
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- Ljung, Lotta (författare)
- Umeå universitet,Reumatologi
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin
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Engstrand, S (författare)
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- Wållberg-Jonsson, Solveig (författare)
- Umeå universitet,Reumatologi
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- Söderberg, Stefan (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Kardiologi
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå universitet,Reumatologi
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Clinical and Experimental Rheumatology. - 0392-856X .- 1593-098X. ; 25:4, s. 617-620
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- BACKGROUND: There is a relationship between cardiovascular morbidity, inflammatory activity, and changes in the lipid profile in rheumatoid arthritis (RA), although the mechanisms are not fully elaborated. Recent know-ledge that white adipose tissue (WAT) is a producer of immunologically and metabolically active substances gives another perspective to study.OBJECTIVE: To evaluate the relationship between interleukin-1 receptor antagonist (IL-1Ra) and variables associated with WAT and inflammation in RA.METHODS: Anthropometric, inflammatory and metabolic variables were assessed in 23 women with RA and 23 matched controls. Spearman, partial correlation and factor analyses were performed.RESULTS: Inflammatory markers were increased in patients. In both groups, IL-1Ra correlated with leptin independent of age and BMI. IL-1Ra also correlated with haptoglobin and apolipoprotein (Apo) B in patients and with soluble TNF receptor (sTNFR) 1 in controls. In factor analysis, three latent factors were identified among patients. The first loaded on IL-1Ra, leptin, BMI, ApoB and body fat content (BF%), the second loaded on IL1-Ra and sTNF-receptors and the third showed inverse loadings on ApoA-I together with loadings on ESR, haptoglobin, orosomucoid, BF% and BMI.CONCLUSION: IL-1Ra was associated with markers of inflammation and with fat-related factors in RA patients, suggesting a dualistic relationship of IL-1Ra in RA. IL-1Ra correlated independently with leptin in both patients and controls, indicating a relationship between inflammation and leptin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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