Sökning: WFRF:(Nilsson Peter M.)
> (2020) >
Glucose-dependent i...
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Jujić, AmraLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
(författare)
Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality : a prospective study
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-01-23
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Springer,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-170391
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170391URI
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https://doi.org/10.1007/s00125-020-05093-9DOI
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https://lup.lub.lu.se/record/76565408-1f54-46e5-9272-c4b065925c13URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aims/hypothesis: Evidence that glucose-dependent insulinotropic peptide (GIP) and/or the GIP receptor (GIPR) are involved in cardiovascular biology is emerging. We hypothesised that GIP has untoward effects on cardiovascular biology, in contrast to glucagon-like peptide 1 (GLP-1), and therefore investigated the effects of GIP and GLP-1 concentrations on cardiovascular disease (CVD) and mortality risk.Methods: GIP concentrations were successfully measured during OGTTs in two independent populations (Malmo Diet Cancer-Cardiovascular Cohort [MDC-CC] and Prevalence, Prediction and Prevention of Diabetes in Botnia [PPP-Botnia]) in a total of 8044 subjects. GLP-1 (n = 3625) was measured in MDC-CC. The incidence of CVD and mortality was assessed via national/regional registers or questionnaires. Further, a two-sample Mendelian randomisation (2SMR) analysis between the GIP pathway and outcomes (coronary artery disease [CAD] and myocardial infarction) was carried out using a GIP-associated genetic variant, rs1800437, as instrumental variable. An additional reverse 2SMR was performed with CAD as exposure variable and GIP as outcome variable, with the instrumental variables constructed from 114 known genetic risk variants for CAD.Results: In meta-analyses, higher fasting levels of GIP were associated with risk of higher total mortality (HR[95% CI] = 1.22 [1.11, 1.35]; p = 4.5 x 10(-5)) and death from CVD (HR[95% CI] 1.30 [1.11, 1.52]; p = 0.001). In accordance, 2SMR analysis revealed that increasing GIP concentrations were associated with CAD and myocardial infarction, and an additional reverse 2SMR revealed no significant effect of CAD on GIP levels, thus confirming a possible effect solely of GIP on CAD.Conclusions/interpretation: In two prospective, community-based studies, elevated levels of GIP were associated with greater risk of all-cause and cardiovascular mortality within 5-9 years of follow-up, whereas GLP-1 levels were not associated with excess risk. Further studies are warranted to determine the cardiovascular effects of GIP per se.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Atabaki-Pasdar, NaeimehLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-nha
(författare)
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Nilsson, Peter MLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Kardiovaskulär forskning - hypertoni,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)medf-mma
(författare)
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Almgren, PeterLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Translational Muscle Research,Lund University Research Groups,Diabetes - Cardiovascular Disease(Swepub:lu)endo-pal
(författare)
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Hakaste, LiisaInstitute for Molecular Medicine Finland (FIMM)
(författare)
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Tuomi, TiinamaijaHelsinki University Central Hospital,Folkhälsan Research Center,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)ti8736tu
(författare)
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Berglund, Lisa MLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)mphy-lni
(författare)
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Franks, Paul W.Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Sweden Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(författare)
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Holst, Jens J.University of Copenhagen
(författare)
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Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-rpa
(författare)
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Torekov, Signe S.University of Copenhagen
(författare)
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Ravassa, SusanaHealth Research Institute of Navarra (IDISNA)
(författare)
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Diez, JavierUniversity Clinic of Navarra
(författare)
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Persson, MargarethaLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-mpe
(författare)
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Melander, OlleLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-ome
(författare)
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Gomez, Maria FLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)mphy-mgo
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Helsinki University Central Hospital(Swepub:lu)endo-lgr
(författare)
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Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah
(författare)
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Magnusson, Martin
(författare)
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer63:5, s. 1043-10540012-186X1432-0428
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Till lärosätets databas
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Jujić, Amra
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Atabaki-Pasdar, ...
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Nilsson, Peter M
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Almgren, Peter
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Hakaste, Liisa
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Tuomi, Tiinamaij ...
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visa fler...
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Berglund, Lisa M
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Franks, Paul W.
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Holst, Jens J.
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Prasad, Rashmi B
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Torekov, Signe S ...
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Ravassa, Susana
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Diez, Javier
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Persson, Margare ...
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Melander, Olle
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Gomez, Maria F
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Groop, Leif
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Ahlqvist, Emma
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Magnusson, Marti ...
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