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Serologic markers o...
Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : Results from the EPIC cohort
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- Idahl, Annika, 1965- (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi
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- Le Cornet, Charlotte (författare)
- German Cancer Research Centre
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- Gonzalez Maldonado, Sandra (författare)
- German Cancer Research Centre
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- Waterboer, Tim (författare)
- German Cancer Research Centre
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- Bender, Noemi (författare)
- German Cancer Research Centre
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Boutron-Ruault, Marie-Christine (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy
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- Fournier, Agnes (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Kvaskoff, Marina (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens
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- Valanou, Elisavet (författare)
- Hellenic Health Foundation, Athens
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht
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- Gram, Inger T. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Quiros, Jose R. (författare)
- Consejería de Salud - Gobierno del Principado de Asturias
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Sanchez, Maria-Jose (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Chirlaque, Maria-Dolores (författare)
- University of Murcia,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Barricarte, Aurelio (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Gil, Leire (författare)
- Biodonostia Health Research Institute
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- Brändstedt, Jenny (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Riesbeck, Kristian (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Microbiology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Lundin, Eva (författare)
- Umeå University,Umeå universitet,Patologi
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Perez-Cornago, Aurora (författare)
- University of Oxford
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Fortner, Renee T. (författare)
- German Cancer Research Centre
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(creator_code:org_t)
- 2020-04-24
- 2020
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 147:8, s. 2042-2052
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case‐control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV‐2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead‐based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22‐4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60‐1) was associated with higher risk of EOC overall (1.36 [1.13‐1.64]) and with the serous subtype (1.44 [1.12‐1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV‐2 was associated with higher risk of endometrioid EOC (2.35 [1.24‐4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV‐2 might promote the development of endometrioid disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Chlamydia trachomatis
- herpes simplex virus
- human papillomavirus
- Mycoplasma genitalium
- ovarian cancer
- Chlamydia trachomatis
- herpes simplex virus
- human papillomavirus
- Mycoplasma genitalium
- ovarian cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Idahl, Annika, 1 ...
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Le Cornet, Charl ...
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Gonzalez Maldona ...
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Waterboer, Tim
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Bender, Noemi
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Tjonneland, Anne
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visa fler...
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Hansen, Louise
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Boutron-Ruault, ...
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Fournier, Agnes
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Kvaskoff, Marina
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Boeing, Heiner
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Trichopoulou, An ...
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Valanou, Elisave ...
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Peppa, Eleni
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Palli, Domenico
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Agnoli, Claudia
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Mattiello, Amali ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Onland-Moret, N. ...
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Gram, Inger T.
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Weiderpass, Elis ...
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Quiros, Jose R.
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Duell, Eric J.
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Sanchez, Maria-J ...
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Gil, Leire
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Brändstedt, Jenn ...
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Riesbeck, Kristi ...
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Lundin, Eva
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Khaw, Kay-Tee
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Perez-Cornago, A ...
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Gunter, Marc J.
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Dossus, Laure
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Kaaks, Rudolf
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Fortner, Renee T ...
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Umeå universitet
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Lunds universitet