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DNA methylation and...
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
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- Haider, Zahra (författare)
- Umeå universitet,Patologi
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- Landfors, Mattias, 1977- (författare)
- Umeå universitet,Patologi
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- Golovleva, Irina (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Erlanson, Martin (författare)
- Umeå universitet,Onkologi
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Schmiegelow, Kjeld (författare)
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Flaegstad, Trond (författare)
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Kanerva, Jukka (författare)
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- Norén-Nyström, Ulrika (författare)
- Umeå universitet,Pediatrik
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- Hultdin, Magnus (författare)
- Umeå universitet,Patologi
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- Degerman, Sofie, 1977- (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Patologi
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(creator_code:org_t)
- 2020-04-28
- 2020
- Engelska.
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Ingår i: Blood Cancer Journal. - : Nature Publishing Group. - 2044-5385. ; 10:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (n = 77) and T-LBL (n = 15) patient samples by high-resolution genome-wide DNA methylation and Copy Number Variation (CNV) BeadChip arrays. DNA methylation profiling identified the presence of CpG island methylator phenotype (CIMP) subgroups within both pediatric and adult T-LBL and T-ALL. An epigenetic signature of 128 differentially methylated CpG sites was identified, that clustered T-LBL and T-ALL separately. The most significant differentially methylated gene loci included the SGCE/PEG10 shared promoter region, previously implicated in lymphoid malignancies. CNV analysis confirmed overlapping recurrent aberrations between T-ALL and T-LBL, including 9p21.3 (CDKN2A/CDKN2B) deletions. A significantly higher frequency of chromosome 13q14.2 deletions was identified in T-LBL samples (36% in T-LBL vs. 0% in T-ALL). This deletion, encompassing the RB1, MIR15A and MIR16-1 gene loci, has been reported as a recurrent deletion in B-cell malignancies. Our study reveals epigenetic and genetic markers that can distinguish between T-LBL and T-ALL, and deepen the understanding of the biology underlying the diverse disease localization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Haider, Zahra
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Landfors, Mattia ...
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Golovleva, Irina
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Erlanson, Martin
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Schmiegelow, Kje ...
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Flaegstad, Trond
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visa fler...
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Kanerva, Jukka
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Norén-Nyström, U ...
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Hultdin, Magnus
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Degerman, Sofie, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Blood Cancer Jou ...
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Umeå universitet