Molecular cloning of the S-adenosylmethionine synthetase gene in Drosophila melanogaster.

• We have isolated and sequenced cDNA clones encoding the Drosophila melanogaster S-adenosylmethionine synthetase. The deduced amino acid sequence contains 405 amino acid residues and shows high homology to rat, yeast, Arabidopsis and Escherichia coli counterparts. The gene is transcribed throughout Drosophila development but its main activity is seen in adult males and females. The highest transcription activity is seen in female ovaries. The transcript has an unusually long 5'-untranslated region, which might be of importance for translational regulation

Nyckelord

Amino Acid Sequence

Animals

Cloning; Molecular

DNA; Complementary

Drosophila melanogaster/*genetics

Female

Gene Expression

Genes; Insect

Male

Methionine Adenosyltransferase/*genetics

Molecular Sequence Data

RNA; Messenger/genetics

Sequence Alignment

Sequence Homology; Amino Acid

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