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The influence of pr...
The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults
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Gylling, Anne Theil (author)
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Eriksen, Christian Skou (author)
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Garde, Ellen (author)
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Wimmelmann, Cathrine Lawaetz (author)
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Reislev, Nina Linde (author)
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Bieler, Theresa (author)
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Ziegler, Andreas Kraag (author)
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Andersen, Kasper Winther (author)
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Bauer, Christian (author)
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Dideriksen, Kasper (author)
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Baekgaard, Maria (author)
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Mertz, Kenneth Hudlebusch (author)
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Bayer, Monika Lucia (author)
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Bloch-Ibenfeldt, Mads (author)
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- Boraxbekk, Carl-Johan, 1980- (author)
- Umeå universitet,Diagnostisk radiologi,Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery M81 and Centre for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen, NV, Denmark; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hvidovre Hospital, Hvidovre, Denmark
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Siebner, Hartwig Roman (author)
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Mortensen, Erik Lykke (author)
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Kjaer, Michael (author)
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Experimental Gerontology. - : Elsevier. - 0531-5565 .- 1873-6815. ; 136
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Physical muscle function and brain hippocampus size declines with age, accelerating after the age of 60. Strength training over a few months improves physical function, but less is known about how long-term strength training affects physical function and hippocampus volume. Therefore, we aimed to investigate the effect of 1-year strength training of two different intensities upon muscle mass, function, and hippocampus volume in retirement-age individuals.Methods: In this multidisciplinary randomized controlled trial (clinicaltrials.gov: NCT02123641), participants were allocated to either a) supervised, heavy resistance training (HRT, n = 149, 3/wk), b) moderate intensity resistance training (MIT, n = 154, 3/wk) or c) non-exercise activities (CON, n = 148). 451 participants were randomized (62-70 yrs., women 61%, approximate to 80% with a chronic medical disease) and 419 were included in the intention-to-treat analysis (n = 143, 144 and 132; HRT, MIT and CON). Changes in muscle power (primary outcome), strength and size, physical function, body composition, hippocampus volume and physical/mental well-being were analyzed.Findings: Of the participants (HRT + MIT), 83% completed training at least 2/week. Leg extensor power was unchanged in all groups, but strength training had a positive effect on isometric knee extensor strength in both groups, whereas an increased muscle mass, cross-sectional area of vastus lateralis muscle, a decreased whole-body fat percentage, visceral fat content and an improved mental health (SF-36) occurred in HRT only. Further, chair-stand performance improved in all groups, whereas hippocampus volume decreased in all groups over time with no influence of strength training.Interpretation: Together, the results indicate that leg extensor power did not respond to long-term supervised strength training, but this type of training in a mixed group of healthy and chronically diseased elderly individuals can be implemented with good compliance and induces consistent changes in physiological parameters of muscle strength, muscle mass and abdominal fat.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Aging
- Body composition
- Physical function
- Resistance exercise
- Physical exercise
- Hippocampus volume
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gylling, Anne Th ...
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Eriksen, Christi ...
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Garde, Ellen
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Wimmelmann, Cath ...
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Reislev, Nina Li ...
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Bieler, Theresa
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Ziegler, Andreas ...
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Andersen, Kasper ...
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Bauer, Christian
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Dideriksen, Kasp ...
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Baekgaard, Maria
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Mertz, Kenneth H ...
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Bayer, Monika Lu ...
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Bloch-Ibenfeldt, ...
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Boraxbekk, Carl- ...
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Siebner, Hartwig ...
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Mortensen, Erik ...
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Kjaer, Michael
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Umeå University