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Physical activity a...
Physical activity and risks of breast and colorectal cancer : a Mendelian randomisation analysis
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Papadimitriou, Nikos (author)
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Dimou, Niki (author)
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Tsilidis, Konstantinos K. (author)
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Banbury, Barbara (author)
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Martin, Richard M. (author)
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Lewis, Sarah J. (author)
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Kazmi, Nabila (author)
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Robinson, Timothy M. (author)
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Albanes, Demetrius (author)
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Aleksandrova, Krasimira (author)
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Berndt, Sonja I. (author)
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Bishop, D. Timothy (author)
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Brenner, Hermann (author)
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Buchanan, Daniel D. (author)
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Bueno-de-Mesquita, Bas (author)
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Campbell, Peter T. (author)
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Castellvi-Bel, Sergi (author)
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Chan, Andrew T. (author)
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Chang-Claude, Jenny (author)
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Ellingjord-Dale, Merete (author)
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Figueiredo, Jane C. (author)
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Gallinger, Steven J. (author)
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Giles, Graham G. (author)
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Giovannucci, Edward (author)
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Gruber, Stephen B. (author)
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Gsur, Andrea (author)
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Hampe, Jochen (author)
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Hampel, Heather (author)
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- Harlid, Sophia, 1978- (author)
- Umeå universitet,Onkologi
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Harrison, Tabitha A. (author)
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Hoffmeister, Michael (author)
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Hopper, John L. (author)
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Hsu, Li (author)
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Maria Huerta, Jose (author)
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Huyghe, Jeroen R. (author)
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Jenkins, Mark A. (author)
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Keku, Temitope O. (author)
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Kuehn, Tilman (author)
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La Vecchia, Carlo (author)
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Le Marchand, Loic (author)
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Li, Christopher I. (author)
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Li, Li (author)
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- Lindblom, Annika (author)
- Karolinska Institutet
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Lindor, Noralane M. (author)
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Lynch, Brigid (author)
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Markowitz, Sanford D. (author)
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Masala, Giovanna (author)
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May, Anne M. (author)
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Milne, Roger (author)
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Monninkhof, Evelyn (author)
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Moreno, Lorena (author)
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Moreno, Victor (author)
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Newcomb, Polly A. (author)
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Offit, Kenneth (author)
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Perduca, Vittorio (author)
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Pharoah, Paul D. P. (author)
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Platz, Elizabeth A. (author)
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Potter, John D. (author)
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Rennert, Gad (author)
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Riboli, Elio (author)
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Sanchez, Maria-Jose (author)
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Schmit, Stephanie L. (author)
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Schoen, Robert E. (author)
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Severi, Gianluca (author)
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Sieri, Sabina (author)
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Slattery, Martha L. (author)
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Song, Mingyang (author)
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Tangen, Catherine M. (author)
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Thibodeau, Stephen N. (author)
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Travis, Ruth C. (author)
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Trichopoulou, Antonia (author)
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Ulrich, Cornelia M. (author)
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van Duijnhoven, Franzel J. B. (author)
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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Vodicka, Pavel (author)
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White, Emily (author)
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi
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Woods, Michael O. (author)
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Wu, Anna H. (author)
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Peters, Ulrike (author)
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Gunter, Marc J. (author)
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Murphy, Neil (author)
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(creator_code:org_t)
- 2020-01-30
- 2020
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 11:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Papadimitriou, N ...
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Dimou, Niki
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Tsilidis, Konsta ...
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Banbury, Barbara
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Martin, Richard ...
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Lewis, Sarah J.
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show more...
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Kazmi, Nabila
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Robinson, Timoth ...
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Albanes, Demetri ...
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Aleksandrova, Kr ...
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Berndt, Sonja I.
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Bishop, D. Timot ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Bueno-de-Mesquit ...
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Campbell, Peter ...
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Castellvi-Bel, S ...
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Chan, Andrew T.
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Chang-Claude, Je ...
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Ellingjord-Dale, ...
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Giovannucci, Edw ...
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Gruber, Stephen ...
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Gsur, Andrea
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Hampe, Jochen
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Hampel, Heather
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Harlid, Sophia, ...
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Harrison, Tabith ...
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Hoffmeister, Mic ...
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Hopper, John L.
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Hsu, Li
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Maria Huerta, Jo ...
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Huyghe, Jeroen R ...
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Jenkins, Mark A.
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Keku, Temitope O ...
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Kuehn, Tilman
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La Vecchia, Carl ...
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Le Marchand, Loi ...
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Li, Christopher ...
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Li, Li
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Lindblom, Annika
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Lindor, Noralane ...
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Lynch, Brigid
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Markowitz, Sanfo ...
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Masala, Giovanna
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May, Anne M.
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Milne, Roger
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Monninkhof, Evel ...
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Moreno, Lorena
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Moreno, Victor
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Newcomb, Polly A ...
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Offit, Kenneth
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Perduca, Vittori ...
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Pharoah, Paul D. ...
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Platz, Elizabeth ...
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Potter, John D.
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Rennert, Gad
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Riboli, Elio
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Sanchez, Maria-J ...
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Schmit, Stephani ...
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Schoen, Robert E ...
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Severi, Gianluca
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Sieri, Sabina
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Slattery, Martha ...
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Song, Mingyang
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Tangen, Catherin ...
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Thibodeau, Steph ...
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Travis, Ruth C.
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Trichopoulou, An ...
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Ulrich, Cornelia ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Vodicka, Pavel
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Peters, Ulrike
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Gunter, Marc J.
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Murphy, Neil
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University
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Uppsala University
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Karolinska Institutet