Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Hampel J) > (2020-2024) > Physical activity a...

Details
MARC

Papadimitriou, Nikos (author)

Physical activity and risks of breast and colorectal cancer : a Mendelian randomisation analysis

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-01-30
Springer Nature,2020
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-173604
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173604URI
https://doi.org/10.1038/s41467-020-14389-8DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427574URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:144062882URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Dimou, Niki (author)
Tsilidis, Konstantinos K. (author)
Banbury, Barbara (author)
Martin, Richard M. (author)
Lewis, Sarah J. (author)
Kazmi, Nabila (author)
Robinson, Timothy M. (author)
Albanes, Demetrius (author)
Aleksandrova, Krasimira (author)
Berndt, Sonja I. (author)
Bishop, D. Timothy (author)
Brenner, Hermann (author)
Buchanan, Daniel D. (author)
Bueno-de-Mesquita, Bas (author)
Campbell, Peter T. (author)
Castellvi-Bel, Sergi (author)
Chan, Andrew T. (author)
Chang-Claude, Jenny (author)
Ellingjord-Dale, Merete (author)
Figueiredo, Jane C. (author)
Gallinger, Steven J. (author)
Giles, Graham G. (author)
Giovannucci, Edward (author)
Gruber, Stephen B. (author)
Gsur, Andrea (author)
Hampe, Jochen (author)
Hampel, Heather (author)
Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105 (author)
Harrison, Tabitha A. (author)
Hoffmeister, Michael (author)
Hopper, John L. (author)
Hsu, Li (author)
Maria Huerta, Jose (author)
Huyghe, Jeroen R. (author)
Jenkins, Mark A. (author)
Keku, Temitope O. (author)
Kuehn, Tilman (author)
La Vecchia, Carlo (author)
Le Marchand, Loic (author)
Li, Christopher I. (author)
Li, Li (author)
Lindblom, AnnikaKarolinska Institutet (author)
Lindor, Noralane M. (author)
Lynch, Brigid (author)
Markowitz, Sanford D. (author)
Masala, Giovanna (author)
May, Anne M. (author)
Milne, Roger (author)
Monninkhof, Evelyn (author)
Moreno, Lorena (author)
Moreno, Victor (author)
Newcomb, Polly A. (author)
Offit, Kenneth (author)
Perduca, Vittorio (author)
Pharoah, Paul D. P. (author)
Platz, Elizabeth A. (author)
Potter, John D. (author)
Rennert, Gad (author)
Riboli, Elio (author)
Sanchez, Maria-Jose (author)
Schmit, Stephanie L. (author)
Schoen, Robert E. (author)
Severi, Gianluca (author)
Sieri, Sabina (author)
Slattery, Martha L. (author)
Song, Mingyang (author)
Tangen, Catherine M. (author)
Thibodeau, Stephen N. (author)
Travis, Ruth C. (author)
Trichopoulou, Antonia (author)
Ulrich, Cornelia M. (author)
van Duijnhoven, Franzel J. B. (author)
van Guelpen, BethanyUmeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)beyvan99 (author)
Vodicka, Pavel (author)
White, Emily (author)
Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516 (author)
Woods, Michael O. (author)
Wu, Anna H. (author)
Peters, Ulrike (author)
Gunter, Marc J. (author)
Murphy, Neil (author)
Umeå universitetOnkologi (creator_code:org_t)

Related titles

In:Nature Communications: Springer Nature11:12041-1723

Internet link

Find in a library

Nature Communications (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Papadimitriou, N ...; Dimou, Niki; Tsilidis, Konsta ...; Banbury, Barbara; Martin, Richard ...; Lewis, Sarah J.; show more...; Kazmi, Nabila; Robinson, Timoth ...; Albanes, Demetri ...; Aleksandrova, Kr ...; Berndt, Sonja I.; Bishop, D. Timot ...; Brenner, Hermann; Buchanan, Daniel ...; Bueno-de-Mesquit ...; Campbell, Peter ...; Castellvi-Bel, S ...; Chan, Andrew T.; Chang-Claude, Je ...; Ellingjord-Dale, ...; Figueiredo, Jane ...; Gallinger, Steve ...; Giles, Graham G.; Giovannucci, Edw ...; Gruber, Stephen ...; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia, ...; Harrison, Tabith ...; Hoffmeister, Mic ...; Hopper, John L.; Hsu, Li; Maria Huerta, Jo ...; Huyghe, Jeroen R ...; Jenkins, Mark A.; Keku, Temitope O ...; Kuehn, Tilman; La Vecchia, Carl ...; Le Marchand, Loi ...; Li, Christopher ...; Li, Li; Lindblom, Annika; Lindor, Noralane ...; Lynch, Brigid; Markowitz, Sanfo ...; Masala, Giovanna; May, Anne M.; Milne, Roger; Monninkhof, Evel ...; Moreno, Lorena; Moreno, Victor; Newcomb, Polly A ...; Offit, Kenneth; Perduca, Vittori ...; Pharoah, Paul D. ...; Platz, Elizabeth ...; Potter, John D.; Rennert, Gad; Riboli, Elio; Sanchez, Maria-J ...; Schmit, Stephani ...; Schoen, Robert E ...; Severi, Gianluca; Sieri, Sabina; Slattery, Martha ...; Song, Mingyang; Tangen, Catherin ...; Thibodeau, Steph ...; Travis, Ruth C.; Trichopoulou, An ...; Ulrich, Cornelia ...; van Duijnhoven, ...; van Guelpen, Bet ...; Vodicka, Pavel; White, Emily; Wolk, Alicja; Woods, Michael O ...; Wu, Anna H.; Peters, Ulrike; Gunter, Marc J.; Murphy, Neil; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

Articles in the publication: Nature Communica ...

By the university: Umeå University; Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se