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Versican accumulate...
Versican accumulates in vascular lesions in pulmonary arterial hypertension
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- Chang, Ya-Ting (författare)
- Karolinska Institutet
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- Chan, Christina K. (författare)
- Benaroya Res Inst Virginia Mason, Matrix Biol Program, Seattle, WA USA.,Benaroya Research Institute
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- Eriksson, Inger (författare)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Johnson, Pamela Y. (författare)
- Benaroya Res Inst Virginia Mason, Matrix Biol Program, Seattle, WA USA.,Benaroya Research Institute
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- Cao, Xiaofang (författare)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Westoo, Christian (författare)
- Lund Univ, Dept Expt Med Sci, BMC C12, S-22184 Lund, Sweden.
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- Norvik, Christian (författare)
- Lund Univ, Dept Expt Med Sci, BMC C12, S-22184 Lund, Sweden.
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- Andersson-Sjöland, Annika (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungbiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lung Biology,Lund University Research Groups
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- Westergren-Thorsson, Gunilla (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungbiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lung Biology,Lund University Research Groups
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- Johansson, Staffan (författare)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Hedin, Ulf (författare)
- Karolinska Institutet
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- Kjellen, Lena (författare)
- Uppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Wight, Thomas N. (författare)
- Benaroya Res Inst Virginia Mason, Matrix Biol Program, Seattle, WA USA.,Benaroya Research Institute
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- Tran-Lundmark, Karin (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Kärlväggsbiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Vessel Wall Biology,Lund University Research Groups
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Karolinska Institutet Benaroya Res Inst Virginia Mason, Matrix Biol Program, Seattle, WA USA (creator_code:org_t)
- 2016-09
- 2016
- Engelska.
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Ingår i: PULMONARY CIRCULATION. - : Wiley. - 2045-8932 .- 2045-8940. ; 6:3, s. 347-359
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.sag...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance. Versican is a chondroitin sulfate proteoglycan in the vascular extracellular matrix that accumulates following vascular injury and promotes smooth-muscle cell proliferation in systemic arteries. Here, we investigated whether versican may play a similar role in PAH. Paraffin-embedded lung sections from patients who underwent lung transplantation to treat PAH were used for immunohistochemistry. The etiologies of PAH in the subjects involved in this study were idiopathic PAH, scleroderma, and congenital heart disease (atrial septal defect) with left-to-right shunt. Independent of the underlying etiology, increased versican immunostaining was observed in areas of medial thickening, in neointima, and in plexiform lesions. Western blot of lung tissue lysates confirmed accumulation of versican in patients with PAH. Double staining for versican and CD45 showed only occasional colocalization in neointima of high-grade lesions and plexiform lesions. In vitro, metabolic labeling with [S-35] sulfate showed that human pulmonary artery smooth-muscle cells (hPASMCs) produce mainly chondroitin sulfate glycosaminoglycans. In addition, hypoxia, but not cyclic stretch, was demonstrated to increase both versican messenger RNA expression and protein synthesis by hPASMCs. Versican accumulates in vascular lesions of PAH, and the amount of versican correlates more with lesion severity than with underlying etiology or inflammation. Hypoxia is a possible regulator of versican accumulation, which may promote proliferation of pulmonary smooth-muscle cells and vascular remodeling in PAH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- pulmonary arterial hypertension
- versican
- vascular smooth-muscle cell
- hypoxia
- mechanical strain
- Hypoxia
- Mechanical strain
- Pulmonary arterial hypertension
- Vascular smooth-muscle cell
- Versican
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chang, Ya-Ting
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Chan, Christina ...
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Eriksson, Inger
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Johnson, Pamela ...
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Cao, Xiaofang
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Westoo, Christia ...
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visa fler...
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Norvik, Christia ...
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Andersson-Sjölan ...
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Westergren-Thors ...
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Johansson, Staff ...
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Hedin, Ulf
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Kjellen, Lena
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Wight, Thomas N.
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Tran-Lundmark, K ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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PULMONARY CIRCUL ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet