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Periodontitis decre...
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Pussinen, PJ
(författare)
Periodontitis decreases the antiatherogenic potency of high density lipoprotein.
- Artikel/kapitelEngelska2004
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LIBRIS-ID:oai:DiVA.org:umu-17421
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-17421URI
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https://doi.org/10.1194/jlr.M300250-JLR200DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic function in cholesterol efflux in vitro. HDL was isolated from 30 patients (age 43.6 +/- 6.1 years, mean +/- SD) with periodontitis before and after (3.2 +/- 1.4 months) periodontal treatment. The capacity of HDL for cholesterol efflux from macrophages (RAW 264.7), HDL composition, and key proteins of HDL metabolism were determined. After periodontal treatment, phospholipid transfer protein (PLTP) activity was 6.2% (P<0.05) lower, and serum HDL cholesterol concentration, PLTP mass, and cholesteryl ester transfer protein activity were 10.7% (P<0.001), 7.1% (P=0.078), and 19.4% (P<0.001) higher, respectively. The mean HDL2/HDL3 ratio increased from 2.16 +/- 0.87 to 3.56 +/- 0.48 (P<0.05). HDL total phospholipid mass and sphingomyelin-phosphatidylcholine ratio were 7.4% (P<0.05) and 36.8% (P<0.001) higher, respectively. The HDL-mediated cholesterol efflux tended to be higher after periodontal treatment; interestingly, this increase was significant (P<0.05) among patients whose C-reactive protein decreased (53.7% reduction, P=0.015) and who were positive by PCR for Actinobacillus actinomycetemcomitans. These results suggest that periodontitis causes similar, but milder, changes in HDL metabolism than those that occur during the acute-phase response and that periodontitis may diminish the antiatherogenic potency of HDL, thus increasing the risk for CHD.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jauhiainen, M
(författare)
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Vilkuna-Rautiainen, T
(författare)
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Sundvall, J
(författare)
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Vesanen, M
(författare)
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Mattila, K
(författare)
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Palosuo, T
(författare)
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Alfthan, G
(författare)
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Asikainen, SirkkaUmeå universitet,Oral mikrobiologi(Swepub:umu)sias0001
(författare)
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Umeå universitetOral mikrobiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Lipid Research45:1, s. 139-1470022-22751539-7262
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