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Intramolecular Pova...
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Adolfsson, Dan E.,1989-Umeå universitet,Kemiska institutionen,Fredrik Almqvist
(author)
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-10-25
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American Chemical Society (ACS),2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-174531
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174531URI
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https://doi.org/10.1021/acs.joc.0c01699DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Previously included in thesis in manuscript form.
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A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with a range of O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycles with diverse substitution. The synthesized compounds were screened for their ability to bind α-synuclein and amyloid β fibrils in vitro. Analogs substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.
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Tyagi, MohitUmeå universitet,Kemiska institutionen(Swepub:umu)moty0009
(author)
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Singh, PardeepUmeå universitet,Kemiska institutionen,Fredrik Almqvist(Swepub:umu)pasi0012
(author)
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Deuschmann, AdrianUmeå universitet,Kemiska institutionen
(author)
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Ådén, Jörgen,1980-Umeå universitet,Kemiska institutionen(Swepub:umu)jonadn02
(author)
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Gharibyan, AnnaUmeå universitet,Institutionen för medicinsk kemi och biofysik,Anders Olofsson(Swepub:umu)angh0001
(author)
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Jayaweera, Sanduni WasanaAnders Olofsson(Swepub:umu)sawa0061
(author)
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Lindgren, Anders E. G.Umeå universitet,Kemiska institutionen,Fredrik Almqvist(Swepub:umu)arslin04
(author)
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Olofsson, Anders,1970-Umeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)anol0042
(author)
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Almqvist, FredrikUmeå universitet,Kemiska institutionen(Swepub:umu)fral0001
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Journal of Organic Chemistry: American Chemical Society (ACS)85:21, s. 14174-141890022-32631520-6904
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Adolfsson, Dan E ...
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Tyagi, Mohit
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Singh, Pardeep
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Deuschmann, Adri ...
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Ådén, Jörgen, 19 ...
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Gharibyan, Anna
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Jayaweera, Sandu ...
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Lindgren, Anders ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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Umeå University