Sökning: WFRF:(Fowler Christopher J.) >
Altered mRNA Expres...
Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue
-
- Alhouayek, Mireille (författare)
- Umeå universitet,Institutionen för farmakologi och klinisk neurovetenskap,Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Bruxelles, Belgium
-
- Boldrup, Linda (författare)
- Umeå universitet,Patologi
-
- Fowler, Christopher J (författare)
- Umeå universitet,Institutionen för farmakologi och klinisk neurovetenskap
-
(creator_code:org_t)
- 2019-08-19
- 2019
- Engelska.
-
Ingår i: Cancer Investigation. - : Informa UK Limited. - 0735-7907 .- 1532-4192. ; 37:8, s. 327-338
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://www.tandfonl...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. Expression of NAPEPLD and PLA2G4E, coding for eCB anabolic enzymes, was higher in the tumour tissue than in non-malignant tissue. Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. It is concluded that the eCB system may be dysfunctional in SCCOT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Squamous cell carcinoma of the oral tongue
- endocannabinoids
- cyclooxygenase-2
- N-acyl- osphatidylethanolamine phospholipase D
- monoacylglycerol lipase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas