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  • Adderley, Jack D. (author)

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-08-11
  • Nature Publishing Group,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-174895
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174895URI
  • https://doi.org/10.1038/s41467-020-17829-7DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Intracellular pathogens mobilize host signaling pathways of their host cell to promote their own survival. Evidence is emerging that signal transduction elements are activated in a-nucleated erythrocytes in response to infection with malaria parasites, but the extent of this phenomenon remains unknown. Here, we fill this knowledge gap through a comprehensive and dynamic assessment of host erythrocyte signaling during infection with Plasmodium falciparum. We used arrays of 878 antibodies directed against human signaling proteins to interrogate the activation status of host erythrocyte phospho-signaling pathways at three blood stages of parasite asexual development. This analysis reveals a dynamic modulation of many host signalling proteins across parasite development. Here we focus on the hepatocyte growth factor receptor (c-MET) and the MAP kinase pathway component B-Raf, providing a proof of concept that human signaling kinases identified as activated by malaria infection represent attractive targets for antimalarial intervention.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • von Freyend, Simona John (author)
  • Jackson, Sarah A. (author)
  • Bird, Megan J. (author)
  • Burns, Amy L. (author)
  • Anar, Burcu (author)
  • Metcalf, Tom (author)
  • Semblat, Jean-Philippe (author)
  • Billker, OliverUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK(Swepub:umu)olbi0005 (author)
  • Wilson, Danny W. (author)
  • Doerig, Christian (author)
  • Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)

Related titles

  • In:Nature Communications: Nature Publishing Group11:12041-1723

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