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Fluckiger, AurélieGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France
(författare)
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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American Association for the Advancement of Science (AAAS),2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-175131
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175131URI
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https://doi.org/10.1126/science.aax0701DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2K(b)-restricted CD8(+) T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Daillere, RomainGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; everImmune, Gustave Roussy Cancer Center, Villejuif, France
(författare)
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Sassi, MohamedUniversité Rennes 1, Laboratoire de Biochimie Pharmaceutique, Inserm U1230 - UPRES EA 2311, Rennes, France
(författare)
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Sixt, Barbara SusanneUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM U1138, Paris, France; Université de Paris, Paris, France; Sorbonne Université, Paris, France(Swepub:umu)basi0006
(författare)
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Liu, PengCell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM U1138, Paris, France; Université de Paris, Paris, France; Sorbonne Université, Paris, France
(författare)
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Loos, FriedemannCell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM U1138, Paris, France; Université de Paris, Paris, France; Sorbonne Université, Paris, France
(författare)
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Richard, CorentinResearch Platform in Biological Oncology, Dijon, France; GIMI Genetic and Immunology Medical Institute, Dijon, France; University of Burgundy-Franche Comté, Dijon, France
(författare)
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Rabu, CatherineCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France; LabEx IGO “Immunotherapy, Graft, Oncology,” Nantes, France
(författare)
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Alou, Maryam TidjaniGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; UMR MEPHI, Aix-Marseille Université, IRD, AP-HM, Institut Hospitalo-Universitaire Méditerranée-Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille cedex 05, France
(författare)
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Goubet, Anne-GaelleGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France
(författare)
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Lemaitre, FabienGustave Roussy Cancer Campus (GRCC), Villejuif, France; everImmune, Gustave Roussy Cancer Center, Villejuif, France
(författare)
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Ferrere, GladysGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France
(författare)
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Derosa, LisaGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; Université Paris-Saclay, Villejuif, F-94805, France
(författare)
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Duong, Connie P. M.Gustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France
(författare)
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Messaoudene, MeriemInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Research Center and Department of Cytology and Pathology, Québec City, Québec, Canada
(författare)
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Gagne, AndreanneInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Research Center and Department of Cytology and Pathology, Québec City, Québec, Canada
(författare)
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Joubert, PhilippeInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Research Center and Department of Cytology and Pathology, Québec City, Québec, Canada
(författare)
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De Sordi, LuisaBacteriophage, Bacterium, Host Laboratory, Institut Pasteur, F-75015 Paris, France; Sorbonne Université, Centre de Recherche Saint Antoine, INSERM UMRS_938, Paris, France
(författare)
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Debarbieux, LaurentBacteriophage, Bacterium, Host Laboratory, Institut Pasteur, F-75015 Paris, France
(författare)
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Simon, SylvainCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France; LabEx IGO “Immunotherapy, Graft, Oncology,” Nantes, France
(författare)
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Scarlata, Clara-MariaCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France; Université Toulouse III Paul Sabatier, 31330 Toulouse, France; Institut Universitaire du Cancer de Toulouse-Oncopole, 31100 Toulouse, France
(författare)
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Ayyoub, MahaCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France; Université Toulouse III Paul Sabatier, 31330 Toulouse, France; Institut Universitaire du Cancer de Toulouse-Oncopole, 31100 Toulouse, France
(författare)
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Palermo, BelindaUnit of Tumor Immunology and Immunotherapy, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy
(författare)
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Facciolo, FrancescoThoracic Surgery Unit, Department of Surgical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy
(författare)
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Boidot, RomainUnit of Molecular Biology, Department of Biology and Pathology of Tumors, Georges-François Leclerc Anticancer Center, UNICANCER, Dijon, France
(författare)
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Wheeler, RichardInstitut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France
(författare)
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Boneca, Ivo GompertsInstitut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France
(författare)
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Sztupinszki, ZsofiaComputational Health Informatics Program (CHIP), Boston Children's Hospital, Boston, MA, USA
(författare)
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Papp, KrisztianDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary
(författare)
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Csabai, IstvanDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary
(författare)
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Pasolli, EdoardoDepartment of Agricultural Sciences, University of Naples Federico II, Naples, Italy
(författare)
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Segata, NicolaDepartment CIBIO, University of Trento, Trento, Italy
(författare)
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Lopez-Otin, CarlosEquipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM U1138, Paris, France; Université de Paris, Paris, France; Sorbonne Université, Paris, France; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
(författare)
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Szallasi, ZoltanComputational Health Informatics Program (CHIP), Boston Children's Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA; Danish Cancer Society Research Center, Copenhagen, Denmark; MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary
(författare)
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Andre, FabriceDepartment of Cancer Medicine, Breast Cancer Committee, Gustave Roussy, Villejuif, France; INSERM Unit 981, Gustave Roussy, Villejuif, France
(författare)
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Iebba, ValerioGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; Department of Medical Sciences, University of Trieste, 34137 Trieste, Italy
(författare)
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Quiniou, ValentinAP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi) and Immunology-Inflammation-Infectiology and Dermatology Department (3iD), F-75651, Paris, France; Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), F-75651, Paris, France
(författare)
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Klatzmann, DavidAP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi) and Immunology-Inflammation-Infectiology and Dermatology Department (3iD), F-75651, Paris, France; Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), F-75651, Paris, France
(författare)
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Boukhalil, JacquesUMR MEPHI, Aix-Marseille Université, IRD, AP-HM, Institut Hospitalo-Universitaire Méditerranée-Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille cedex 05, France
(författare)
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Khelaifia, SaberUMR MEPHI, Aix-Marseille Université, IRD, AP-HM, Institut Hospitalo-Universitaire Méditerranée-Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille cedex 05, France
(författare)
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Raoult, DidierUMR MEPHI, Aix-Marseille Université, IRD, AP-HM, Institut Hospitalo-Universitaire Méditerranée-Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille cedex 05, France
(författare)
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Albiges, LaurenceGustave Roussy Cancer Campus (GRCC), Villejuif, France; Department of Medical Oncology, Gustave Roussy, Villejuif, France
(författare)
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Escudier, Bernardustave Roussy Cancer Campus (GRCC), Villejuif, France; Department of Medical Oncology, Gustave Roussy, Villejuif, France; INSERM U981, GRCC, Villejuif, France
(författare)
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Eggermont, AlexanderGustave Roussy Cancer Campus (GRCC), Villejuif, France; Princess Maxima Center, CS 3584 Utrecht, the Netherlands
(författare)
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Mami-Chouaib, FathiaINSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Fac. de Médecine - Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France
(författare)
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Nistico, PaolaUnit of Tumor Immunology and Immunotherapy, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy; Thoracic Surgery Unit, Department of Surgical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy
(författare)
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Ghiringhelli, FrancoisDepartment of Medical Oncology, Center GF Leclerc, Dijon, France
(författare)
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Routy, BertrandInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Research Center and Department of Cytology and Pathology, Québec City, Québec, Canada; Division d'Hémato-Oncologie, Département de Médicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada
(författare)
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Labarriere, NathalieCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France; LabEx IGO “Immunotherapy, Graft, Oncology,” Nantes, France
(författare)
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Cattoir, VincentUniversité Rennes 1, Laboratoire de Biochimie Pharmaceutique, Inserm U1230 - UPRES EA 2311, Rennes, France; CHU de Rennes - Hôpital Ponchaillou, Service de Bactériologie-Hygiène Hospitalière, Rennes, France; CNR de la Résistance aux Antibiotiques (laboratoire associé 'Entérocoques'), Rennes, France.
(författare)
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Kroemer, GuidoCell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM U1138, Paris, France; Université de Paris, Paris, France. Sorbonne Université, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique–Hôpitaux de Paris, Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden; Suzhou Institute for Systems Biology, Chinese Academy of Medical Sciences, Suzhou, China; Institut Universitaire de France, Paris, France
(författare)
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Zitvogel, LaurenceGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; Université Paris-Saclay, Villejuif, F-94805, France; Suzhou Institute for Systems Biology, Chinese Academy of Medical Sciences, Suzhou, China
(författare)
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Gustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, FranceGustave Roussy Cancer Campus (GRCC), Villejuif, France; Institut National de la Santé et de la Recherche Médicale, U1015, Institut Gustave Roussy, Villejuif, France; everImmune, Gustave Roussy Cancer Center, Villejuif, France
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Science: American Association for the Advancement of Science (AAAS)369:6506, s. 936-9420036-80751095-9203
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Fluckiger, Aurél ...
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Daillere, Romain
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Sassi, Mohamed
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Sixt, Barbara Su ...
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Liu, Peng
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Loos, Friedemann
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visa fler...
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Richard, Corenti ...
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Rabu, Catherine
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Alou, Maryam Tid ...
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Goubet, Anne-Gae ...
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Lemaitre, Fabien
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Ferrere, Gladys
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Derosa, Lisa
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Duong, Connie P. ...
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Messaoudene, Mer ...
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Gagne, Andreanne
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Joubert, Philipp ...
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De Sordi, Luisa
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Debarbieux, Laur ...
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Simon, Sylvain
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Scarlata, Clara- ...
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Ayyoub, Maha
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Palermo, Belinda
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Facciolo, France ...
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Boidot, Romain
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Wheeler, Richard
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Boneca, Ivo Gomp ...
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Sztupinszki, Zso ...
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Papp, Krisztian
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Csabai, Istvan
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Pasolli, Edoardo
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Segata, Nicola
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Szallasi, Zoltan
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Andre, Fabrice
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Iebba, Valerio
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