SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Desplan Claude)
 

Sökning: WFRF:(Desplan Claude) > Neuronal diversity ...

  • Özel, Mehmet Neset (författare)

Neuronal diversity and convergence in a visual system developmental atlas

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2020-11-04
  • Nature Publishing Group,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-176801
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176801URI
  • https://doi.org/10.1038/s41586-020-2879-3DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Deciphering how neuronal diversity is established and maintained requires a detailed knowledge of neuronal gene expression throughout development. In contrast to mammalian brains(1,2), the large neuronal diversity of the Drosophila optic lobe(3) and its connectome(4-6) are almost completely characterized. However, a molecular characterization of this neuronal diversity, particularly during development, has been lacking. Here we present insights into brain development through a nearly complete description of the transcriptomic diversity of the optic lobes of Drosophila. We acquired the transcriptome of 275,000 single cells at adult and at five pupal stages, and built a machine-learning framework to assign them to almost 200 cell types at all time points during development. We discovered two large neuronal populations that wrap neuropils during development but die just before adulthood, as well as neuronal subtypes that partition dorsal and ventral visual circuits by differential Wnt signalling throughout development. Moreover, we show that the transcriptomes of neurons that are of the same type but are produced days apart become synchronized shortly after their production. During synaptogenesis we also resolved neuronal subtypes that, although differing greatly in morphology and connectivity, converge to indistinguishable transcriptomic profiles in adults. Our datasets almost completely account for the known neuronal diversity of the Drosophila optic lobes, and serve as a paradigm to understand brain development across species. The neuronal diversity of the Drosophila optic lobe is described throughout pupal development by single-cell sequencing, leading to the discovery of transient extrinsic neurons and a dorsoventral asymmetry of the visual circuits.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Simon, Felix (författare)
  • Jafari, Shadi,1973-Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biology, New York University, New York, NY, USA(Swepub:umu)shja0011 (författare)
  • Holguera, Isabel (författare)
  • Chen, Yen-Chung (författare)
  • Benhra, Najate (författare)
  • El-Danaf, Rana Naja (författare)
  • Kapuralin, Katarina (författare)
  • Malin, Jennifer Amy (författare)
  • Konstantinides, Nikolaos (författare)
  • Desplan, Claude (författare)
  • Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature: Nature Publishing Group589, s. 88-950028-08361476-4687

Internetlänk

Hitta via bibliotek

  • Nature (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy