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Liver-expressed Cd3...
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
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Brown, Richard J. P. (author)
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Tegtmeyer, Birthe (author)
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Sheldon, Julie (author)
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Khera, Tanvi (author)
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Todt, Daniel (author)
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Vieyres, Gabrielle (author)
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Weller, Romy (author)
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Joecks, Sebastian (author)
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Zhang, Yudi (author)
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Sake, Svenja (author)
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Bankwitz, Dorothea (author)
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Welsch, Kathrin (author)
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Ginkel, Corinne (author)
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Engelmann, Michael (author)
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- Gerold, Gisa, 1979- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany,Gisa Gerold
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Steinmann, Eike (author)
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Yuan, Qinggong (author)
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Ott, Michael (author)
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Vondran, Florian W. R. (author)
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Krey, Thomas (author)
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Ströh, Luisa J. (author)
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Miskey, Csaba (author)
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Ivics, Zoltán (author)
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Herder, Vanessa (author)
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Baumgärtner, Wolfgang (author)
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Lauber, Chris (author)
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Seifert, Michael (author)
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Tarr, Alexander W. (author)
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McClure, C. Patrick (author)
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Randall, Glenn (author)
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Baktash, Yasmine (author)
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Ploss, Alexander (author)
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Thi, Viet Loan Dao (author)
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Michailidis, Eleftherios (author)
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Saeed, Mohsan (author)
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Verhoye, Lieven (author)
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Meuleman, Philip (author)
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Goedecke, Natascha (author)
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Wirth, Dagmar (author)
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Rice, Charles M. (author)
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Pietschmann, Thomas (author)
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(creator_code:org_t)
- American Association for the Advancement of Science, 2020
- 2020
- English.
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In: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 6:45
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infection of rodents, murine liver complementary DNA library screening was performed, identifying transmembrane proteins Cd302 and Cr1l as potent restrictors of HCV propagation. Combined ectopic expression in human hepatoma cells impeded HCV uptake and cooperatively mediated transcriptional dysregulation of a noncanonical program of immunity genes. Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict HCV were observed between the murine orthologs and their human counterparts. Genetic ablation of endogenous Cd302 expression in human HCV entry factor transgenic mice increased hepatocyte permissiveness for an adapted HCV strain and dysregulated expression of metabolic process and host defense genes. These findings highlight human-mouse differences in liver-intrinsic antiviral immunity and facilitate the development of next-generation murine models for preclinical testing of HCV vaccine candidates.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Brown, Richard J ...
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Tegtmeyer, Birth ...
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Sheldon, Julie
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Khera, Tanvi
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Todt, Daniel
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Vieyres, Gabriel ...
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show more...
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Weller, Romy
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Joecks, Sebastia ...
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Zhang, Yudi
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Sake, Svenja
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Bankwitz, Doroth ...
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Welsch, Kathrin
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Ginkel, Corinne
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Engelmann, Micha ...
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Gerold, Gisa, 19 ...
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Steinmann, Eike
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Yuan, Qinggong
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Ott, Michael
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Vondran, Florian ...
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Krey, Thomas
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Ströh, Luisa J.
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Miskey, Csaba
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Ivics, Zoltán
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Herder, Vanessa
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Baumgärtner, Wol ...
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Lauber, Chris
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Seifert, Michael
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Tarr, Alexander ...
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McClure, C. Patr ...
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Randall, Glenn
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Baktash, Yasmine
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Ploss, Alexander
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Thi, Viet Loan D ...
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Michailidis, Ele ...
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Saeed, Mohsan
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Verhoye, Lieven
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Meuleman, Philip
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Goedecke, Natasc ...
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Wirth, Dagmar
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Rice, Charles M.
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Pietschmann, Tho ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Science Advances
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Umeå University