id:"swepub:oai:DiVA.org:umu-177284"
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- Holm, Caroline (author)
Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia
- Article/chapterEnglish2006
Publisher, publication year, extent ...
- Elsevier,2006
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-177284
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177284URI
- https://doi.org/10.1016/j.leukres.2005.07.010DOI
- https://lup.lub.lu.se/record/143450URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
- Cyclin A1
- Acute lymphoblastic leukemia
- Disease characteristics
- Event free survival
- Cell cycle
- Cyclin dependent kinase
- cyclin A1
- cyclin dependent kinase
- event
- acute lymphoblastic leukemia
- free survival
- cell cycle
- disease characteristics
Added entries (persons, corporate bodies, meetings, titles ...)
- Øra, IngridLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)molm-ior (author)
- Brunhoff, CeciliaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)gen-cbr (author)
- Anagnostaki, Lola (author)
- Landberg, GöranLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-gla (author)
- Persson, Jenny L.,ProfessorLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)medk-jpe (author)
- Wigerup, CarolineLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Patologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-cho (author)
- Pediatrik, LundSektion V (creator_code:org_t)
Related titles
- In:Leukemia Research: Elsevier30:3, s. 254-2610145-21261873-5835
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16182364&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1016/j.leukres.2005.07.010FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177284
- https://doi.org/10.1016/j.leukres.2005.07.010
- https://lup.lub.lu.se/record/143450
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