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Increased Plasma So...
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Keindl, MagdalenaUniversity of Bergen
(author)
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-10-30
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Frontiers Media S.A.2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-177316
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177316URI
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https://doi.org/10.3389/fendo.2020.575469DOI
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https://lup.lub.lu.se/record/6a36fcac-d656-4ce6-942e-1d06e79d3a81URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145131226URI
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https://gup.ub.gu.se/publication/299710URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic beta cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who do not progress to vascular complications offer a great potential to evaluate end-organ protection. The aim of the present study was to investigate the association of inflammatory protein levels with vascular complications (retinopathy, nephropathy, cardiovascular disease) in individuals with long-term T1D compared to individuals who rapidly progressed to complications. We studied a panel of inflammatory markers in plasma of patients with long-term T1D with (n = 81 and 26) and without (n = 313 and 25) vascular complications from two cross-sectional Scandinavian cohorts (PROLONG and DIALONG) using Luminex technology. A subset of PROLONG individuals (n = 61) was screened for circulating immune cells using multicolor flow cytometry. We found that elevated plasma levels of soluble interleukin-2 receptor alpha (sIL-2R) were positively associated with the complication phenotype. Risk carriers of polymorphisms in the IL2RA and PTPN2 gene region had elevated plasma levels of sIL-2R. In addition, cell surface marker analysis revealed a shift from naive to effector T cells in T1D individuals with vascular complications as compared to those without. In contrast, no difference between the groups was observed either in IL-2R cell surface expression or in regulatory T cell population size. In conclusion, our data indicates that IL2RA and PTPN2 gene variants might increase the risk of developing vascular complications in people with T1D, by affecting sIL-2R plasma levels and potentially lowering T cell responsiveness. Thus, elevated sIL-2R plasma levels may serve as a biomarker in monitoring the risk for developing diabetic complications and thereby improve patient care.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Fedotkina, OlenaUniversity of Bergen(Swepub:lu)ol3543fe
(author)
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du Plessis, ElsaUniversity of Bergen
(author)
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Jain, RuchiLund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)med-ruj
(author)
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Bergum, BrithKarolinska Institutet
(author)
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Mygind Jensen, TroelsSteno Diabetes Center Copenhagen,University of Southern Denmark
(author)
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Laustrup Moller, CathrineSteno Diabetes Center Copenhagen
(author)
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Falhammar, HenrikKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(author)
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Nyström, ThomasKarolinska Institutet
(author)
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Catrina, Sergiu-BogdanKarolinska Institute,Karolinska University Hospital
(author)
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Jörneskog, GunDanderyd Hospital
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki(Swepub:lu)endo-lgr
(author)
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Eliasson, MatsUmeå University,Umeå universitet,Avdelningen för medicin(Swepub:umu)mael0021
(author)
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Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xelibj
(author)
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Brismar, KerstinKarolinska Institutet
(author)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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Berg, Tore JulsrudUniversity of Oslo
(author)
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Appel, SilkeUniversity of Bergen
(author)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Bergen(Swepub:lu)endo-vly
(author)
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University of BergenDiabetes - öpatofysiologi
(creator_code:org_t)
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In:Frontiers in Endocrinology: Frontiers Media S.A.111664-2392
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Fedotkina, Olena
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Jain, Ruchi
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Bergum, Brith
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Mygind Jensen, T ...
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Laustrup Moller, ...
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Falhammar, Henri ...
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Groop, Leif
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Eliasson, Mats
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Eliasson, Björn, ...
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Brismar, Kerstin
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Nilsson, Peter M ...
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Berg, Tore Julsr ...
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