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  • Keindl, MagdalenaUniversity of Bergen (author)

Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-10-30
  • Frontiers Media S.A.2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-177316
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177316URI
  • https://doi.org/10.3389/fendo.2020.575469DOI
  • https://lup.lub.lu.se/record/6a36fcac-d656-4ce6-942e-1d06e79d3a81URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145131226URI
  • https://gup.ub.gu.se/publication/299710URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic beta cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who do not progress to vascular complications offer a great potential to evaluate end-organ protection. The aim of the present study was to investigate the association of inflammatory protein levels with vascular complications (retinopathy, nephropathy, cardiovascular disease) in individuals with long-term T1D compared to individuals who rapidly progressed to complications. We studied a panel of inflammatory markers in plasma of patients with long-term T1D with (n = 81 and 26) and without (n = 313 and 25) vascular complications from two cross-sectional Scandinavian cohorts (PROLONG and DIALONG) using Luminex technology. A subset of PROLONG individuals (n = 61) was screened for circulating immune cells using multicolor flow cytometry. We found that elevated plasma levels of soluble interleukin-2 receptor alpha (sIL-2R) were positively associated with the complication phenotype. Risk carriers of polymorphisms in the IL2RA and PTPN2 gene region had elevated plasma levels of sIL-2R. In addition, cell surface marker analysis revealed a shift from naive to effector T cells in T1D individuals with vascular complications as compared to those without. In contrast, no difference between the groups was observed either in IL-2R cell surface expression or in regulatory T cell population size. In conclusion, our data indicates that IL2RA and PTPN2 gene variants might increase the risk of developing vascular complications in people with T1D, by affecting sIL-2R plasma levels and potentially lowering T cell responsiveness. Thus, elevated sIL-2R plasma levels may serve as a biomarker in monitoring the risk for developing diabetic complications and thereby improve patient care.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fedotkina, OlenaUniversity of Bergen(Swepub:lu)ol3543fe (author)
  • du Plessis, ElsaUniversity of Bergen (author)
  • Jain, RuchiLund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)med-ruj (author)
  • Bergum, BrithKarolinska Institutet (author)
  • Mygind Jensen, TroelsSteno Diabetes Center Copenhagen,University of Southern Denmark (author)
  • Laustrup Moller, CathrineSteno Diabetes Center Copenhagen (author)
  • Falhammar, HenrikKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
  • Nyström, ThomasKarolinska Institutet (author)
  • Catrina, Sergiu-BogdanKarolinska Institute,Karolinska University Hospital (author)
  • Jörneskog, GunDanderyd Hospital (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki(Swepub:lu)endo-lgr (author)
  • Eliasson, MatsUmeå University,Umeå universitet,Avdelningen för medicin(Swepub:umu)mael0021 (author)
  • Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xelibj (author)
  • Brismar, KerstinKarolinska Institutet (author)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Berg, Tore JulsrudUniversity of Oslo (author)
  • Appel, SilkeUniversity of Bergen (author)
  • Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Bergen(Swepub:lu)endo-vly (author)
  • University of BergenDiabetes - öpatofysiologi (creator_code:org_t)

Related titles

  • In:Frontiers in Endocrinology: Frontiers Media S.A.111664-2392

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