Vitronectin: a promising breast cancer serum biomarker for early diagnosis of breast cancer in patients

Vitronectin : a promising breast cancer serum biomarker for early diagnosis of breast cancer in patients

Breast cancer is the most common cancer in women worldwide, identification of new biomarkers for early diagnosis and detection will improve the clinical outcome of breast cancer patients. In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assays. Serum VN level was significantly higher in patients with stage 0-I primary breast cancer than in healthy individuals, patients with benign breast lesion or precancerous lesions, as well as those with breast cancer of higher stages. Serum VN level was significantly and negatively correlated with tumor size, lymph node status, and clinical stage (p < 0.05 in all cases). In addition, VN displayed higher area under curve (AUC) value (0.73, 95 % confidence interval (CI) [0.62-0.84]) than carcinoembryonic antigen (CEA) (0.64, 95 % CI [0.52-0.77]) and cancer antigen 15-3 (CA 15-3) (0.69, 95 % CI [0.58-0.81]) when used to distinguish stage 0-I cancer and normal control. Importantly, the combined use of three biomarkers yielded an improvement in receiver operating characteristic curve with an AUC of 0.83, 95 % CI [0.74-0.92]. Taken together, our current study showed for the first time that serum VN is a promising biomarker for early diagnosis of breast cancer when combined with CEA and CA15-3.

Zhang, Xuhui (författare)
Xiu, Bingshui (författare)
Yang, Xiqin (författare)
Hu, Shuofeng (författare)
Liu, Zhiqiang (författare)
Duan, Cuimi (författare)
Jin, Shujuan (författare)
Ying, Xiaomin (författare)
Zhao, Yanfeng (författare)
Han, Xiaowei (författare)
Hao, Xiaopeng (författare)
Fan, Yawen (författare)
Johnson, Heather (författare)
Meng, Di (författare)
Persson, Jenny L.,ProfessorLund University,Lunds universitet,Experimentell cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Experimental Cancer Research, Malmö,Lund University Research Groups(Swepub:lu)medk-jpe (författare)
Zhang, Heqiu (författare)
Feng, XiaoYan (författare)
Huang, Yan (författare)
Experimentell cancerforskning, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Av författaren/redakt...: Hao, Wende; Zhang, Xuhui; Xiu, Bingshui; Yang, Xiqin; Hu, Shuofeng; Liu, Zhiqiang; visa fler...; Duan, Cuimi; Jin, Shujuan; Ying, Xiaomin; Zhao, Yanfeng; Han, Xiaowei; Hao, Xiaopeng; Fan, Yawen; Johnson, Heather; Meng, Di; Persson, Jenny L ...; Zhang, Heqiu; Feng, XiaoYan; Huang, Yan; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.