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Sökning: WFRF:(Riklund A) > (2020-2023) > Immune responses ag...

Immune responses against autologous tumor and human papilloma virus in lymph nodes from patients with penile cancer

Zhang, Lu (författare)
Zirakzadeh, A. Ali (författare)
Umeå universitet,Urologi och andrologi
Rosvall, Jesper (författare)
Karolinska Institutet
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Hedlund, Mats (författare)
Hu, Ping-Sheng (författare)
Riklund, Katrine, MD, PhD, Professor, 1963- (författare)
Umeå universitet,Diagnostisk radiologi
Sherif, Amir (författare)
Umeå universitet,Urologi och andrologi
Winqvist, Ola (författare)
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 (creator_code:org_t)
The Korean Urological Association, 2021
2021
Engelska.
Ingår i: Investigative and Clinical Urology. - : The Korean Urological Association. - 2466-0493 .- 2466-054X. ; 62
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE: Nearly half of penile cancers are related to human papillomavirus (HPV) infection. Investigations of tumor- and HPV-specific T cell reactivity in regional lymph nodes (LNs) from patients with penile cancer are warranted.MATERIALS AND METHODS: In this study, single-cell suspensions from LNs and peripheral blood from 11 patients with penile cancer were stained with antibodies for lymphocyte markers and analyzed by fluorescence-activated cell sorting (FACS). DNA was extracted from the tumor tissue and HPV status was investigated by PCR.RESULTS: T-cell reactivity against autologous tumor-extract and against the HPV-vaccine Gardasil® was tested by flow-cytometric assay of specific cell-mediated immune response in activated whole blood (FASCIA). CD4+/CD8+ ratios were significantly lower in HPV positive LNs (p<0.05). Immune responses to tumor extract assessed by blast transformation and expansion in vitro, of either CD4+ or CD8+ T-cells, were found in 9 of 13 LNs (69%). 5 of 6 tested patients demonstrated T cell recognition of tumor-associated antigen(s). In HPV-positive patients, dose-dependent T cell responses against L1 (late) HPV proteins (Gardasil vaccine) were demonstrated.CONCLUSIONS: LN-derived T cells from patients with penile cancer recognize tumor antigen(s) and in HPV-positive cases, there is a response against L1 (late) HPV proteins, being constituents of the Gardasil vaccine.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

Adoptive immunity
Lymph node excision
Papillomaviridae
Penile neoplasms
T-lymphocytes

Publikations- och innehållstyp

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