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NfL as a biomarker ...
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Bäckström, David C,M.D.1978-Umeå universitet,Neurovetenskaper
(författare)
NfL as a biomarker for neurodegeneration and survival in Parkinson disease
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Wolters Kluwer,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-178856
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178856URI
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https://doi.org/10.1212/WNL.0000000000010084DOI
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https://gup.ub.gu.se/publication/299461URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE: To determine whether neurofilament light chain protein in CSF (cNfL), a sensitive biomarker of neuroaxonal damage, reflects disease severity or can predict survival in Parkinson disease (PD).METHODS: We investigated whether disease severity, phenotype, or survival in patients with new-onset PD correlates with cNfL concentrations around the time of diagnosis in the population-based New Parkinsonism in Umeå (NYPUM) study cohort (n = 99). A second, larger new-onset PD cohort (n = 194) was used for independent validation. Association of brain pathology with the cNfL concentration was examined with striatal dopamine transporter imaging and repeated diffusion tensor imaging at baseline and 1 and 3 years.RESULTS: Higher cNfL in the early phase of PD was associated with greater severity of all cardinal motor symptoms except tremor in both cohorts and with shorter survival and impaired olfaction. cNfL concentrations above the median of 903 ng/L conferred an overall 5.8 times increased hazard of death during follow-up. After adjustment for age and sex, higher cNfL correlated with striatal dopamine transporter uptake deficits and lower fractional anisotropy in diffusion tensor imaging of several axonal tracts.CONCLUSIONS: cNfL shows usefulness as a biomarker of disease severity and to predict survival in PD. The present results indicate that the cNfL concentration reflects the intensity of the neurodegenerative process, which could be important in future clinical trials.CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with PD, cNfL concentrations are associated with more severe disease and shorter survival.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Linder, JanUmeå universitet,Neurovetenskaper(Swepub:umu)jali0020
(författare)
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Jakobson Mo, SusannaUmeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)suja0009
(författare)
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Riklund, Katrine,MD, PhD, Professor,1963-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)kaah0001
(författare)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(författare)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(författare)
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Forsgren, LarsUmeå universitet,Neurovetenskaper
(författare)
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Lenfeldt, NiklasUmeå universitet,Neurovetenskaper(Swepub:umu)nislet97
(författare)
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Umeå universitetNeurovetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neurology: Wolters Kluwer95:7, s. e827-e8380028-38781526-632X
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