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Gut microbiota-spec...
Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis
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Pröbstel, Anne-Katrin (author)
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Zhou, Xiaoyuan (author)
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Baumann, Ryan (author)
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Wischnewski, Sven (author)
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Kutza, Michael (author)
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Rojas, Olga L. (author)
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Sellrie, Katrin (author)
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Bischof, Antje (author)
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Kim, Kicheol (author)
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Ramesh, Akshaya (author)
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Dandekar, Ravi (author)
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Greenfield, Ariele L. (author)
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Schubert, Ryan D. (author)
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Bisanz, Jordan E. (author)
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Vistnes, Stephanie (author)
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Khaleghi, Khashayar (author)
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Landefeld, James (author)
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Kirkish, Gina (author)
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Liesche-Starnecker, Friederike (author)
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Ramaglia, Valeria (author)
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Singh, Sneha (author)
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Tran, Edwina B. (author)
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Barba, Patrick (author)
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Zorn, Kelsey (author)
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Oechtering, Johanna (author)
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- Forsberg, Karin (author)
- Umeå universitet,Patologi,Neurovetenskaper
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Shiow, Lawrence R. (author)
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Henry, Roland G. (author)
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Graves, Jennifer (author)
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Cree, Bruce A. C. (author)
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Hauser, Stephen L. (author)
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Kuhle, Jens (author)
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Gelfand, Jeffrey M. (author)
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- Andersen, Peter M., 1962- (author)
- Umeå universitet,Neurovetenskaper
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Schlegel, Jürgen (author)
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Turnbaugh, Peter J. (author)
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Seeberger, Peter H. (author)
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Gommerman, Jennifer L. (author)
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Wilson, Michael R. (author)
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Schirmer, Lucas (author)
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Baranzini, Sergio E. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science, 2020
- 2020
- English.
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In: Science immunology. - : American Association for the Advancement of Science. - 2470-9468. ; 5:53
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and what role IgA+ cells have in neuroinflammation are unknown. Here, we identify IgA-bound taxa in MS and show that IgA-producing cells specific for MS-associated taxa traffic to the inflamed CNS, resulting in a strong, compartmentalized IgA enrichment in active MS and other neuroinflammatory diseases. Unlike previously characterized polyreactive anti-commensal IgA responses, CNS IgA cross-reacts with surface structures on specific bacterial strains but not with brain tissue. These findings establish gut microbiota-specific IgA+ cells as a systemic mediator in MS and suggest a critical role of mucosal B cells during active neuroinflammation with broad implications for IgA as an informative biomarker and IgA-producing cells as an immune subset to harness for therapeutic interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Neurology
- neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Pröbstel, Anne-K ...
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Zhou, Xiaoyuan
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Baumann, Ryan
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Wischnewski, Sve ...
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Kutza, Michael
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Rojas, Olga L.
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show more...
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Sellrie, Katrin
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Bischof, Antje
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Kim, Kicheol
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Ramesh, Akshaya
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Dandekar, Ravi
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Greenfield, Arie ...
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Schubert, Ryan D ...
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Bisanz, Jordan E ...
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Vistnes, Stephan ...
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Khaleghi, Khasha ...
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Landefeld, James
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Kirkish, Gina
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Liesche-Starneck ...
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Ramaglia, Valeri ...
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Singh, Sneha
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Tran, Edwina B.
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Barba, Patrick
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Zorn, Kelsey
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Oechtering, Joha ...
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Forsberg, Karin
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Shiow, Lawrence ...
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Henry, Roland G.
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Graves, Jennifer
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Cree, Bruce A. C ...
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Hauser, Stephen ...
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Kuhle, Jens
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Gelfand, Jeffrey ...
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Andersen, Peter ...
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Schlegel, Jürgen
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Turnbaugh, Peter ...
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Seeberger, Peter ...
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Gommerman, Jenni ...
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Wilson, Michael ...
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Schirmer, Lucas
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Baranzini, Sergi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Science immunolo ...
- By the university
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Umeå University