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Global Characterisa...
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) : A CENTER-TBI Analysis
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- Böhm, Julia K. (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany
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- Güting, Helge (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany
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- Thorn, Sophie (author)
- Emergency and Trauma Centre, Alfred Health, Melbourne, Australia
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- Schäfer, Nadine (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany
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- Rambach, Victoria (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany
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- Schöchl, Herbert (author)
- Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria
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- Grottke, Oliver (author)
- Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany
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- Rossaint, Rolf (author)
- Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany
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- Stanworth, Simon (author)
- NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK
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- Curry, Nicola (author)
- NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK
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- Lefering, Rolf (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany
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- Maegele, Marc (author)
- Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany; MaeDepartment of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Cologne, Germany
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Vámos, Zoltán (author)
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- Koskinen, Lars-Owe D., Professor, 1955- (contributor)
- Umeå universitet,Neurovetenskaper
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- Brorsson, Camilla (author)
- Umeå universitet,Anestesiologi och intensivvård
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2020-12-11
- 2020
- English.
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In: Neurocritical Care. - : Encyclopedia of Global Archaeology/Springer Verlag. - 1541-6933 .- 1556-0961. ; 35:1, s. 184-196
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Abstract
Subject headings
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- Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.Methods: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis.Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly.Conclusion: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- CENTER-TBI
- Traumatic brain injury
- Coagulopathy
- Risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Böhm, Julia K.
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Güting, Helge
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Thorn, Sophie
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Schäfer, Nadine
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Rambach, Victori ...
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Schöchl, Herbert
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Grottke, Oliver
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Rossaint, Rolf
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Stanworth, Simon
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Curry, Nicola
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Lefering, Rolf
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Maegele, Marc
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Vámos, Zoltán
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Koskinen, Lars-O ...
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Brorsson, Camill ...
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Oresic, Matej, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurocritical Ca ...
- By the university
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Umeå University
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Örebro University
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Karolinska Institutet