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  • Böhm, Julia K.Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany (author)

Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) : A CENTER-TBI Analysis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-12-11
  • Encyclopedia of Global Archaeology/Springer Verlag,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-179981
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179981URI
  • https://doi.org/10.1007/s12028-020-01151-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88032URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145356640URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.Methods: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis.Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly.Conclusion: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Güting, HelgeDepartment of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany (author)
  • Thorn, SophieEmergency and Trauma Centre, Alfred Health, Melbourne, Australia (author)
  • Schäfer, NadineDepartment of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany (author)
  • Rambach, VictoriaDepartment of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany (author)
  • Schöchl, HerbertDepartment of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria (author)
  • Grottke, OliverDepartment of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany (author)
  • Rossaint, RolfDepartment of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany (author)
  • Stanworth, SimonNHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK (author)
  • Curry, NicolaNHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK (author)
  • Lefering, RolfDepartment of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany (author)
  • Maegele, MarcDepartment of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany; MaeDepartment of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Cologne, Germany (author)
  • Vámos, Zoltán (author)
  • Koskinen, Lars-Owe D.,Professor,1955-Umeå universitet,Neurovetenskaper(Swepub:umu)lako0002 (contributor)
  • Brorsson, CamillaUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)brca0001(author)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)moc(author)
  • Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, GermanyEmergency and Trauma Centre, Alfred Health, Melbourne, Australia (creator_code:org_t)

Related titles

  • In:Neurocritical Care: Encyclopedia of Global Archaeology/Springer Verlag35:1, s. 184-1961541-69331556-0961

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