SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Gamo J)
 

Sökning: WFRF:(Gamo J) > The antimalarial ef...

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

Miguel-Blanco, Celia (författare)
Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain
Murithi, James M. (författare)
Department of Microbiology and Immunology, Columbia University Irving Medical Center, NY, New York, United States
Benavente, Ernest Diez (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
visa fler...
Angrisano, Fiona (författare)
Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, United Kingdom
Sala, Katarzyna A. (författare)
Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom
van Schalkwyk, Donelly A. (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Vanaerschot, Manu (författare)
Department of Microbiology and Immunology, Columbia University Irving Medical Center, NY, New York, United States
Schwach, Frank (författare)
Parasites and Microbes Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Fuchter, Matthew J. (författare)
Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, Wood Lane, London, United Kingdom
Billker, Oliver (författare)
Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Parasites and Microbes Programme, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Sutherland, Colin J. (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Campino, Susana G. (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Clark, Taane G. (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Blagborough, Andrew M. (författare)
Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, United Kingdom; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom
Fidock, David A. (författare)
Department of Microbiology and Immunology, Columbia University Irving Medical Center, NY, New York, United States; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, NY, New York, United States
Herreros, Esperanza (författare)
Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain; Medicines for Malaria Venture, 20 Route de Pré-Bois, Geneva 15, Switzerland
Gamo, Francisco Javier (författare)
Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain
Baum, Jake (författare)
Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom
Delves, Michael J. (författare)
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
visa färre...
 (creator_code:org_t)
2021-01-21
2021
Engelska.
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten control programmes. Plasmodium, the apicomplexan parasite responsible for malaria, causes disease pathology through repeated cycles of invasion and replication within host erythrocytes (the asexual cycle). Antimalarial drugs primarily target this cycle, seeking to reduce parasite burden within the host as fast as possible and to supress recrudescence for as long as possible. Intense phenotypic drug screening efforts have identified a number of promising new antimalarial molecules. Particularly important is the identification of compounds with new modes of action within the parasite to combat existing drug resistance and suitable for formulation of efficacious combination therapies. Here we detail the antimalarial properties of DDD01034957—a novel antimalarial molecule which is fast-acting and potent against drug resistant strains in vitro, shows activity in vivo, and possesses a resistance mechanism linked to the membrane transporter PfABCI3. These data support further medicinal chemistry lead-optimization of DDD01034957 as a novel antimalarial chemical class and provide new insights to further reduce in vivo metabolic clearance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy