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Sex-dimorphic genet...
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
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- Lagou, Vasiliki (author)
- University of Oxford,Catholic University of Leuven,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Katholieke Univ Leuven, Lab Adapt Immun, Dept Microbiol & Immunol, Leuven, Belgium.;VIB KU Leuven Ctr Brain & Dis Res, Leuven, Belgium.
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- Maegi, Reedik (author)
- Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
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- Hottenga, Jouke- Jan (author)
- Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam, Netherlands.
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- Grallert, Harald (author)
- Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;German Ctr Diabet Res DZD, Munich, Germany.
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- Perry, John R. B. (author)
- Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland.,CESP Ctr Res Epidemiol & Publ Hlth, Inserm, U1018, Villejuif, France.;Univ Paris Sud, Univ Paris Saclay, UVSQ, UMRS 1018,UMRS 1018, Villejuif, France.
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- Bouatia-Naji, Nabila (author)
- Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Paris Cardiovasc Res Ctr PARCC, INSERM U970, F-75006 Paris, France.
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- Marullo, Letizia (author)
- Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
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- Rybin, Denis (author)
- Boston Univ, Data Coordinating Ctr, Boston, MA 02215 USA.
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- Jansen, Rick (author)
- Karolinska Institutet
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- Lind, Lars (author)
- Karolinska Institutet,Uppsala universitet,Klinisk epidemiologi,Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.,Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
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- Dimas, Antigone S. (author)
- Biomed Sci Res Ctr Al, Inst Bioinnovat, Vari, Greece.,CNR, Ist Ric Genet & Biomed, Monserrato, Italy.;Univ Groningen, Univ Med Ctr, Dept Genet, Groningen, Netherlands.
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- Ulrich, Anna (author)
- Imperial Coll, Dept Med, London, England.,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
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- Zudina, Liudmila (author)
- Imperial Coll, Dept Med, London, England.
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- Gadin, Jesper R. (author)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiovasc Med Unit,Ctr Mol Med, Solna, Sweden.
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- Jiang, Longda (author)
- Imperial Coll, Dept Med, London, England.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.
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- Faggian, Alessia (author)
- Imperial Coll, Dept Med, London, England.
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- Bonnefond, Amelie (author)
- Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Imperial Coll, Dept Med, London, England.
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- Fadista, Joao (author)
- Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
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- Stathopoulou, Maria G. (author)
- Univ Lorraine, IGE PCV, F-54000 Nancy, France.
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- Isaacs, Aaron (author)
- Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Maastricht Univ, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands.;Maastricht Univ, Maastricht Ctr Syst Biol MaCSBio, Maastricht, Netherlands.;Maastricht Univ, Dept Physiol, Maastricht, Netherlands.
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- Willems, Sara M. (author)
- Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.
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- Navarro, Pau (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
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- Tanaka, Toshiko (author)
- NIA, Translat Gerontol Branch, Longitudinal Study Sect, Baltimore, MD 21224 USA.,Univ Geneva, Med Sch, Dept Genet Med & Dev, Geneva, Switzerland.
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Jackson, Anne U. (author)
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- Montasser, May E. (author)
- Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.
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- O'Connell, Jeff R. (author)
- Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.
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- Bielak, Lawrence F. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
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- Webster, Rebecca J. (author)
- Univ Western Australia, Med Res Ctr, Harry Perkins Inst Med Res, Lab Canc Med, Nedlands, WA, Australia.
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- Saxena, Richa (author)
- Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.;MGH, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA.
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- Stafford, Jeanette M. (author)
- Wake Forest Univ, Div Publ Hlth Sci, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA.
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- Pourcain, Beate St (author)
- Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Bristol, Avon, England.
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- Timpson, Nicholas J. (author)
- Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Bristol, Avon, England.
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- Salo, Perttu (author)
- Finnish Inst Hlth & Welf, Dept Chron Dis Prevent, Publ Hlth Genom Unit, Helsinki, Finland.
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- Shin, So-Youn (author)
- Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.
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- Amin, Najaf (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.,Univ Dundee, Pat McPherson Ctr Pharmacogenet & Pharmacogenom, Div Mol & Clin Med, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland.
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- Smith, Albert V. (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.;Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.,Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
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- Li, Guo (author)
- Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Med, Seattle, WA USA.
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- Verweij, Niek (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
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- Goel, Anuj (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Cardiovasc Med, Oxford, England.
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- Ford, Ian (author)
- Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland.
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- Johnson, Paul C. D. (author)
- Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland.;Queen Mary Univ London, Barts & London Sch Med & Dent, Glasgow, Lanark, Scotland.
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- Johnson, Toby (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Unit, London, England.
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- Kapur, Karen (author)
- Karolinska Institutet
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- Thorleifsson, Gudmar (author)
- deCODE Genet, Reykjavik, Iceland.
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- Strawbridge, Rona J. (author)
- Dept Med, Cardiovasc Med Unit, Solna, Sweden.;Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Ctr Mol Med, Stockholm, Sweden.;Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.
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- Rasmussen-Torvik, Laura J. (author)
- Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
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- Esko, Tonu (author)
- Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
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- Mihailov, Evelin (author)
- Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
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- Fall, Tove, 1979- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Fraser, Ross M. (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.;Synpr Ltd, Roslin Innovat Ctr, Easter Bush Campus, Edinburgh EH25 9RG, Midlothian, Scotland.
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- Mahajan, Anubha (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Genentech Inc, 340 Point San Bruno Blvd, San Francisco, CA 94080 USA.
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- Kanoni, Stavroula (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Wellcome Trust Sanger Inst, Hinxton, England.
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Kleber, Marcus E. (author)
- Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.
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- Silbernagel, Guenther (author)
- Med Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria.
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- Meyer, Julia (author)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.
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- Mueller-Nurasyid, Martina (author)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol & Chair Genet Epidemiol, Munich, Germany.;Ludwig Maximilians Univ Munchen, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, IMBEI, D-55101 Mainz, Germany.
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- Ganna, Andrea (author)
- Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA USA.;Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA.
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- Sarin, Antti-Pekka (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Finnish Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.
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- Yengo, Loic (author)
- Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.
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- Shungin, Dmitry (author)
- Umeå universitet,Institutionen för odontologi,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.;Skane Univ Hosp Malmö, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmö, Sweden.;Umeå Univ, Dept Odontol, Umeå, Sweden.
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- Luan, Jian'an (author)
- Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.
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- Horikoshi, Momoko (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;RIKEN, Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa, Japan.
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- An, Ping (author)
- Washington Univ, Div Stat Genom, Sch Med, Washington, DC USA.
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- Sanna, Serena (author)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Med, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA USA.
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- Boettcher, Yvonne (author)
- Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.
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- Rayner, N. William (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Wellcome Trust Sanger Inst, Hinxton, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Nolte, Ilja M. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
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- Zemunik, Tatijana (author)
- Univ Split, Fac Med, Split, Croatia.
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- Iperen, Erik van (author)
- Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands.
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- Kovacs, Peter (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.
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- Hastie, Nicholas D. (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
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- Wild, Sarah H. (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
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- McLachlan, Stela (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
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- Campbell, Susan (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
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- Polasek, Ozren (author)
- Univ Split, Fac Med, Split, Croatia.
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- Carlson, Olga (author)
- NIA, Lab Clin Invest, Baltimore, MD 21224 USA.
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- Egan, Josephine (author)
- NIA, Lab Clin Invest, Baltimore, MD 21224 USA.
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- Kiess, Wieland (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Womens & Child Hlth, Pediat Res Ctr, Leipzig, Germany.
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- Willemsen, Gonneke (author)
- Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.
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- Kuusisto, Johanna (author)
- Univ Eastern Finland, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.
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- Laakso, Markku (author)
- Univ Eastern Finland, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.
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- Dimitriou, Maria (author)
- Harokopio Univ, Dept Dietet Nutr, Athens, Greece.
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- Hicks, Andrew A. (author)
- Univ Lubeck Lubeck Germany, Ctr Biomed, European Acad Bozen Bolzano EURAC, Affiliated Inst, Bolzano, Italy.
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- Rauramaa, Rainer (author)
- Univ Groningen, Dept Endocrinol, Univ Med Ctr Groningen, Groningen, Netherlands.,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.,Tech Univ Dresden, Dept Med, Div Prevent & Care Diabet, Fac Med Carl Gustav Carus, Dresden, Germany.,Cardiol Grp, Frankfurt, Germany.,Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.;Regeneron Pharmaceut, Regeneron Genet Ctr, Tarrytown, NY USA.
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- Bandinelli, Stefania (author)
- Azienda Sanitaria Firenze ASF, Geriatr Unit, Florence, Italy.
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- Thorand, Barbara (author)
- German Ctr Diabet Res DZD, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
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- Liu, Yongmei (author)
- Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27101 USA.
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- Miljkovic, Iva (author)
- Univ Pittsburgh, Ctr Aging & Populat Hlth, Dept Epidemiol, Pittsburgh, PA USA.
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Lind, Lars (author)
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- Doney, Alex (author)
- Univ Dundee, Pat McPherson Ctr Pharmacogenet & Pharmacogenom, Div Mol & Clin Med, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland.
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- Perola, Markus (author)
- Finnish Inst Hlth & Welf, Dept Chron Dis Prevent, Publ Hlth Genom Unit, Helsinki, Finland.;Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Hingorani, Aroon (author)
- UCL, Dept Epidemiol & Publ Hlth, London, England.
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- Kivimaki, Mika (author)
- UCL, Dept Epidemiol & Publ Hlth, London, England.
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- Kumari, Meena (author)
- UCL, Dept Epidemiol & Publ Hlth, London, England.;Univ Essex, Wivenhoe Pk, Colchester, Essex, England.
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- Bennett, Amanda J. (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Groves, Christopher J. (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Herder, Christian (author)
- German Ctr Diabet Res DZD, Munich, Germany.;Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
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- Koistinen, Heikki A. (author)
- Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.;Univ Helsinki, Dept Med, POB 340Haartmaninkatu 4, FI-00029 Helsinki, Finland.;Univ Helsinki, Cent Hosp, POB 340Haartmaninkatu 4, FI-00029 Helsinki, Finland.;Biomedicum 2U, Minerva Fdn Inst Med Res, Tukholmankatu 8, FI-00290 Helsinki, Finland.
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- Kinnunen, Leena (author)
- Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.
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- Faire, Ulf de (author)
- Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
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- Bakker, Stephan J. L. (author)
- Finnish Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.
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- Uusitupa, Matti (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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Palmer, Colin N. A. (author)
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- Jukema, J. Wouter (author)
- Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.;Netherlands Heart Inst, Utrecht, Netherlands.
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- Sattar, Naveed (author)
- Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
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- Pouta, Anneli (author)
- Finnish Inst Hlth & Welf, Dept Govt Serv, Helsinki, Finland.;Oulu Univ Hosp, PEDEGO Res Unit, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.
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- Snieder, Harold (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
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- Boerwinkle, Eric (author)
- Univ Texas Hlth Sci Ctr Houston, IMM Ctr Human Genet, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol, Houston, TX 77030 USA.
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Pankow, James S. (author)
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Magnusson, Patrik K. (author)
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- Krus, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.
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- Scapoli, Chiara (author)
- Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
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- de Geus, Eco J. C. N. (author)
- Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam, Netherlands.
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- Blueher, Matthias (author)
- Univ Leipzig, Dept Med, Leipzig, Germany.;USC, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.
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Wolffenbuttel, Bruce H. R. (author)
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- Province, Michael A. (author)
- Washington Univ, Div Stat Genom, Sch Med, Washington, DC USA.
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Abecasis, Goncalo R. (author)
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- Meigs, James B. (author)
- Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Gen Med Div, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
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- Hovingh, G. Kees (author)
- Amsterdam UMC, Dept Vasc Med, Amsterdam, Netherlands.;Novo Nordisk AS, Copenhagen, Denmark.
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Lindstroem, Jaana (author)
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- Wilson, James F. (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
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- Wright, Alan F. (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
-
- Dedoussis, George V. (author)
- Harokopio Univ, Dept Dietet Nutr, Athens, Greece.
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Bornstein, Stefan R. (author)
-
- Schwarz, Peter E. H. (author)
- Karolinska Institutet
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- Toenjes, Anke (author)
- Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.
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Winkelmann, Bernhard R. (author)
-
- Boehm, Bernhard O. (author)
- Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.
-
- Maerz, Winfried (author)
- Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany.
-
- Metspalu, Andres (author)
- Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
-
- Price, Jackie F. (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
-
- Deloukas, Panos (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Wellcome Trust Sanger Inst, Hinxton, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia.
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- Koerner, Antje (author)
- Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA.
-
- Lakka, Timo A. (author)
- Kuopio Res Inst Exercise Med, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.
-
- Keinanen-Kiukaanniemi, Sirkka M. (author)
- Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu, Finland.;Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
-
- Saaristo, Timo E. (author)
- Finnish Diabet Assoc, Tampere, Finland.;Pirkanmaa Hosp Dist, Tampere, Finland.
-
- Bergman, Richard N. (author)
- Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA USA.
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- Tuomilehto, Jaakko (author)
- Finnish Diabet Assoc, Helsinki, Finland.;Inst Biomed Physiol, Helsinki, Finland.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.
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- Wareham, Nicholas J. (author)
- Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.
-
- Langenberg, Claudia (author)
- Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.
-
- Maennistoe, Satu (author)
- Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.
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- Franks, Paul W. (author)
- Umeå universitet,Avdelningen för medicin,Näringsforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Skane Univ Hosp Malmö, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmö, Sweden.;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Umeå Univ, Units Med & Nutr Res, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Hayward, Caroline (author)
- Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
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Vitart, Veronique (author)
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- Kaprio, Jaakko (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Inst Biomed Physiol, Helsinki, Finland.
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- Visvikis-Siest, Sophie (author)
- Univ Lorraine, IGE PCV, F-54000 Nancy, France.
-
- Balkau, Beverley (author)
- NIA, Geriatr Epidemiol Sect, Lab Epidemiol, Bethesda, MD USA.,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Unit, London, England.
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- Altshuler, David (author)
- Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
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- Rudan, Igor (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
-
- Stumvoll, Michael (author)
- Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.
-
- Campbell, Harry (author)
- Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.
-
- van Duijn, Cornelia M. (author)
- Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Ctr Med Syst Biol, Leiden, Netherlands.
-
- Gieger, Christian (author)
- Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
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- Illig, Thomas (author)
- Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.;Hannover Med Sch, Inst Human Genet, Hannover, Germany.
-
- Ferrucci, Luigi (author)
- Natl Inst Aging, Clin Res Branch, Baltimore, MD USA.
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Pedersen, Nancy L. (author)
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- Pramstaller, Peter P. (author)
- Univ Lubeck Lubeck Germany, Ctr Biomed, European Acad Bozen Bolzano EURAC, Affiliated Inst, Bolzano, Italy.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany.,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Manchester, Lancs, England.
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- Boehnke, Michael (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
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- Frayling, Timothy M. (author)
- Univ Exeter, Genet Complex Traits, Peninsula Med Sch, Exeter, Devon, England.
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Shuldiner, Alan R. (author)
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- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
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Kardia, Sharon L. R. (author)
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- Univ Adelaide, Sch Publ Hlth, Adelaide, SA, Australia.
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- Penninx, Brenda W. (author)
- Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
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- Meneton, Pierre (author)
- Ctr Rech Cordeliers, INSERM, U872, F-75006 Paris, France.
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Harris, Tamara B. (author)
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- Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
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- Harst, Pim van der (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
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- Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England.
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- Forouhi, Nita G. (author)
- Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.
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Loos, Ruth J. F. (author)
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- Salomaa, Veikko (author)
- Finnish Inst Hlth & Welf, Helsinki, Finland.
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- Soranzo, Nicole (author)
- Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.
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- Boomsma, Dorret I. (author)
- Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.;Univ Helsinki, Abdominal Ctr, Endocrinol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Res Program Clin & Mol Metab, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.
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- Hofman, Albert (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Netherlands Consortium Hlth Ageing, The Hague, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
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Munroe, Patricia B. (author)
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- Gudnason, Vilmundur (author)
- Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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Siscovick, David S. (author)
-
- Watkins, Hugh (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Cardiovasc Med, Oxford, England.
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- Lecoeur, Cecile (author)
- Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.
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- Vollenweider, Peter (author)
- Univ Lausanne Hosp, Dept Med, Lausanne, Switzerland.
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet
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- Eriksson, Per (author)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiovasc Med Unit,Ctr Mol Med, Solna, Sweden.
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- Jarvelin, Marjo-Riitta (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Imperial Coll London, HPA MRC Ctr, Sch Publ Hlth, London, England.;Univ Oulu, Inst Hlth Sci, Oulu, Finland.
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- Stefansson, Kari (author)
- deCODE Genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Hamsten, Anders (author)
- Karolinska Institutet
-
- Nicholson, George (author)
- Univ Oxford, Dept Stat, Oxford, England.
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- Karpe, Fredrik (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Oxford Natl Inst Hlth, Res Biomed Res Ctr, Oxford, England.
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Dermitzakis, Emmanouil T. (author)
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- Lindgren, Cecilia M. (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England.
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- McCarthy, Mark I. (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Oxford Natl Inst Hlth, Res Biomed Res Ctr, Oxford, England.;Genentech Inc, 340 Point San Bruno Blvd, San Francisco, CA 94080 USA.
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- Froguel, Philippe (author)
- Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Imperial Coll, Dept Med, London, England.
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- Kaakinen, Marika A. (author)
- Imperial Coll, Dept Med, London, England.;Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford, Surrey, England.
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.;Univ Bergen, Dept Clin Sci, Bergen, Norway.
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- Watanabe, Richard M. (author)
- USC, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.;USC, Keck Sch Med, Dept Physiol & Neurosci, Los Angeles, CA USA.;USC Diabet & Obes Res Inst, Los Angeles, CA USA.
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
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- Florez, Jose C. (author)
- Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA.
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- Dupuis, Josee (author)
- Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA.
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- Barroso, Ines (author)
- Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.;Univ Cambridge, Metab Res Labs, Cambridge, England.;Univ Cambridge, NIHR Cambridge Biomed Res Ctr, Cambridge, England.;Univ Exeter, Exeter Ctr ExcEllence Diabet ExCEED, Sch Med, Exeter, Devon, England.
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Morris, Andrew P. (author)
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- Prokopenko, Inga (author)
- University of Surrey,Wellcome Trust Centre for Human Genetics,Imperial College London,Institute of Biochemistry and Genetics, Ufa Scientific Center RAS,University of Oxford,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Imperial Coll, Dept Med, London, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford, Surrey, England.;Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa, Russia.;Univ Exeter, Exeter Ctr ExcEllence Diabet ExCEED, Sch Med, Exeter, Devon, England.
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Iperen, Ev (author)
-
Faire, Ud (author)
-
Harst, Pvd (author)
-
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(creator_code:org_t)
- 2021-01-05
- 2021
- English.
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 12:1
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Abstract
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- Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Umeå University
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Karolinska Institutet