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Human Embryonic Ste...
Human Embryonic Stem Cell-derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats
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- Jones, Iwan (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Institutionen för integrativ medicinsk biologi (IMB)
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- Novikova, Liudmila N. (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Wiberg, Mikael (författare)
- Umeå universitet,Anatomi,Handkirurgi
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- Carlsson, Leif (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Novikov, Lev N. (författare)
- Umeå universitet,Anatomi
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(creator_code:org_t)
- 2021-01-31
- 2021
- Engelska.
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Ingår i: Cell Transplantation. - : Sage Publications. - 0963-6897 .- 1555-3892. ; 30
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Spinal cord injury results in irreversible tissue damage and permanent sensorimotor impairment. The development of novel therapeutic strategies that improve the life quality of affected individuals is therefore of paramount importance. Cell transplantation is a promising approach for spinal cord injury treatment and the present study assesses the efficacy of human embryonic stem cell-derived neural crest cells as preclinical cell-based therapy candidates. The differentiated neural crest cells exhibited characteristic molecular signatures and produced a range of biologically active trophic factors that stimulated in vitro neurite outgrowth of rat primary dorsal root ganglia neurons. Transplantation of the neural crest cells into both acute and chronic rat cervical spinal cord injury models promoted remodeling of descending raphespinal projections and contributed to the partial recovery of forelimb motor function. The results achieved in this proof-of-concept study demonstrates that human embryonic stem cell-derived neural crest cells warrant further investigation as cell-based therapy candidates for the treatment of spinal cord injury.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- hESCs
- motor recovery
- neural crest cells
- spinal cord injury
- transplantation
- vertical cylinder test
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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