Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

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Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Strangfeld, Anja (författare): Epidemiology and Health Care Research, German Rheumatism Research Center (DRFZ Berlin), Berlin, Germany

Schäfer, Martin (författare): Epidemiology and Health Care Research, German Rheumatism Research Center (DRFZ Berlin), Berlin, Germany

Gianfrancesco, Milena A. (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

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Lawson-Tovey, Saskia (författare): Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom; National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

Liew, Jean W. (författare): Section of Rheumatology, Department of Medicine, Boston University School of Medicine, MA, Boston, United States

Ljung, Lotta, 1964- (författare): Karolinska Institutet,Umeå universitet,Reumatologi,Clinical Epidemiology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Mateus, Elsa F. (författare): Portuguese League Against Rheumatic Diseases (LPCDR), Lisbon, Portugal; European League Against Rheumatism (EULAR), Standing Committee of People with Arthritis/Rheumatism in Europe (PARE), Kilchberg, Switzerland

Richez, Christophe (författare): Club Rhumatismes et Inflammation (CRI), Immune-Mediated Inflammatory Disease Alliance for Translational and Clinical Research Network (IMIDIATE), Bordeaux, France

Santos, Maria J. (författare): Rheumatology Department, Hospital Garcia de Orta, Almada, Portugal; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal

Schmajuk, Gabriela (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Scirè, Carlo A. (författare): Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan, Italy; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

Sirotich, Emily (författare): Department of Health Research Methods Evidence, and Impact, McMaster University, ON, Hamilton, Canada; Canadian Arthritis Patient Alliance, ON, Toronto, Canada

Sparks, Jeffrey A. (författare): Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, MA, Boston, United States

Sufka, Paul (författare): Healthpartners, MN, St. Paul, United States

Thomas, Thierry (författare): Société Française de Rhumatologie (SFR), Saint Etienne, France; Department of Rheumatology, Hôpital Nord, CHU Saint-Etienne, Saint-Etienne, France; INSERM U1059, Université de Lyon-Université Jean Monnet, Saint-Etienne, France

Trupin, Laura (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Wallace, Zachary S. (författare): Clinical Epidemiology Program and Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States

Al-Adely, Sarah (författare): National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

Bachiller-Corral, Javier (författare): Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto de investigación IRYCIS, Universidad de Alcalá, Madrid, Spain

Bhana, Suleman (författare): Crystal Run Healthcare, Middletown, United States

Cacoub, Patrice (författare): Département de Médecine Interne et Immunologie Clinique, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France; Société Nationale Française de Médecine Interne (SNFMI), Paris, France

Carmona, Loreto (författare): Instituto de Salud Musculoesquelética, Madrid, Spain

Costello, Ruth (författare): Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

Costello, Wendy (författare): Irish Children's Arthritis Network (iCAN), Tipperary, Ireland

Gossec, Laure (författare): Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Sorbonne Université, Paris, France; AP-HP.Sorbonne Université, Rheumatology department, Pitié-Salpêtrière hospital, Paris, France

Grainger, Rebecca (författare): University of Otago, Wellington, New Zealand

Hachulla, Eric (författare): Filière des maladies Auto-Immunes et Autoinflammatoires Rares (FAI2R), Lille University, France, Lille University, Lille, France

Hasseli, Rebecca (författare): Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Ustus-Liebig-University Giessen, Giessen, Germany

Hausmann, Jonathan S. (författare): Program in Rheumatology, Boston Children's Hospital, MA, Boston, United States; Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, Boston, United States

Hyrich, Kimme L. (författare): National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

Izadi, Zara (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Jacobsohn, Lindsay (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Katz, Patricia (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Kearsley-Fleet, Lianne (författare): Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

Robinson, Philip C. (författare): Faculty of Medicine, University of Queensland, QLD, Brisbane, Australia; Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, QLD, Herston, Australia

Yazdany, Jinoos (författare): Division of Rheumatology, Department of Medicine, University of California, CA, San Francisco, United States

Machado, Pedro M. (författare): National Institute for Health Research (NIHR), University College London Hospitals Biomedical Research Centre, University College London Hospitals National Health Service (NHS) Trust, London, United Kingdom; Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare, NHS TrustLondon North West University Healthcare NHS Trust, London, United Kingdom; Centre for Rheumatology, UCL Division of Medicine, Department of Neuromuscular Diseases, University College London, London, United Kingdom

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2021-01-27
2021
Engelska.
Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 80:7, s. 930-942

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://ard.bmj.com/...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Objectives: To determine factors associated with COVID-19-related death in people with rheumatic diseases.Methods: Physician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category.Results: Of 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs ≤65 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death.Conclusion: Among people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

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Av lärosätet: Umeå universitet; Karolinska Institutet

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Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry

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