Metabolic factors and the risk of small intestine cancers: pooled study of 800 000 individuals in the Metabolic syndrome and Cancer project

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Metabolic factors and the risk of small intestine cancers : pooled study of 800 000 individuals in the Metabolic syndrome and Cancer project

Nagel, Gabriele (författare): Ulm Univ, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany.;Agcy Prevent & Social Med Aks, Bregenz, Austria.,University of Ulm

Bjørge, Tone (författare): Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway.,Cancer Registry of Norway, Institute of Population-Based Cancer Research,University of Bergen

Jaensch, Andrea (författare): Ulm Univ, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany.,University of Ulm

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Peter, Raphael S. (författare): Ulm Univ, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany.,University of Ulm

Häggström, Christel (författare): Uppsala University,Umeå University,Uppsala universitet,Umeå universitet,Näringsforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.

Lang, Alois (författare): Agcy Prevent & Social Med Aks, Bregenz, Austria.,Agency for Preventive and Social Medicine Vorarlberg

Engeland, Anders (författare): Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway.,Norwegian Institute of Public Health,University of Bergen

Teleka, Stanley (författare): Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments

Jirström, Karin (författare): Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments

Lindquist, David (författare): Umeå University,Umeå universitet,Professionell utveckling,Umeå Univ, Dept Clin Sci, Umeå, Sweden.

Stattin, Pär (författare): Uppsala University,Uppsala universitet,Urologkirurgi

Ulmer, Hanno (författare): Med Univ Innsbruck, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria.,Medical University of Innsbruck

Concin, Hans (författare): Agcy Prevent & Social Med Aks, Bregenz, Austria.

Stocks, Tanja (författare): Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

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Ulm Univ, Inst Epidemiol & Med Biometry, Helmholtzstr 22, D-89081 Ulm, Germany;Agcy Prevent & Social Med Aks, Bregenz, Austria. University of Ulm (creator_code:org_t)

2021-03-04
2021
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 149:1, s. 66-74

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To explore the largely unknown etiology of small intestine cancer, we examined metabolic factors and risk of small intestine cancer overall and by subtypes. Amongst 404 220 women and 403 265 men in six European cohorts, we applied Cox regression with adjustment for smoking and body mass index (BMI), to calculate sex-specific hazard ratios (HR) of small intestine cancer by levels of BMI, mean arterial pressure (MAP), and plasma total cholesterol, triglycerides and glucose. We also calculated HRs for these factors combined (metabolic score; MetS) and used Wald test statistics to investigate pairwise interactions between metabolic factors on risk. We also performed analyses separately per subtype (neuroendocrine tumors (NETs) and adenocarcinomas). During a median follow-up of 16.9 years, 144 women and 195 men were diagnosed with small intestine cancer, including 184 NETs and 99 adenocarcinomas. Among men, no main associations or interactions between metabolic factors were observed in relation to the risk of small intestine cancer. Among women, triglycerides were positively and linearly associated with risk (HR per standard deviation [SD]: 1.23, 95% CI 1.04 to 1.46), and a positive association was also observed for the MetS (HR per SD: 1.25, 95% CI 1.02 to 1.52). Positive interactions were observed among women between triglycerides and cholesterol (p=0.0005), and between MAP and glucose (p=0.009), on risk. Glucose was positively associated with adenocarcinomas among women. This large, prospective study suggests that elevated triglycerides, and metabolic factors in interaction, confer an increased risk of small intestine cancer among women, but not among men.

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Av författaren/redakt...: Nagel, Gabriele; Bjørge, Tone; Jaensch, Andrea; Peter, Raphael S ...; Häggström, Chris ...; Lang, Alois; visa fler...; Engeland, Anders; Teleka, Stanley; Jirström, Karin; Lindquist, David; Stattin, Pär; Ulmer, Hanno; Concin, Hans; Stocks, Tanja; visa färre...

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Av lärosätet: Umeå universitet; Uppsala universitet; Lunds universitet

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Metabolic factors and the risk of small intestine cancers : pooled study of 800 000 individuals in the Metabolic syndrome and Cancer project

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