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- Franks, PaulUmeå universitet,Medicin (författare)
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity.
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
- American Physiological Society,2007
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-18138
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18138URI
- https://doi.org/10.1152/japplphysiol.01022.2006DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Leptin regulates a constellation of neuroendocrine processes that control energy homeostasis. The infusion of leptin in rodents lacking endogenous leptin promotes physical activity energy expenditure (PAEE) and improves insulin signaling, whereas hyperleptinemia is associated with physical inactivity and insulin resistance (IR). We tested whether baseline leptin levels predict changes in PAEE and IR over time, independent of obesity. We also assessed whether the relationship between leptin and change in IR is mediated by PAEE. The population consisted of 288 nondiabetic UK Caucasian adults (mean age: 49.4 yr; SD: 0.7 yr), in whom leptin, insulin, glucose, PAEE (via heart rate monitoring with individual calibration by indirect calorimetry), and anthropometric characteristics had been measured at baseline and 5 yr later. In linear regression models, baseline leptin levels inversely predicted follow-up PAEE ( P = 0.033). On average, individuals with low leptin levels (below sex-specific median) increased their daily activity 35% more during the 5-yr follow-up period than those with above-median leptin levels. Baseline leptin level also predicted worsening IR (fasting, 30-min, and 2-h insulins, and homeostasis model assessment-IR; all P < 0.01). Associations were independent of potential confounders, such as adiposity, age, and sex. Including baseline PAEE as a cofactor in the leptin-insulin models reduced the strength (1–4% reduction) and significance of the associations, suggesting that PAEE mediates the leptin-insulin relationships. Hyperleptinemia predicts a relative decline in PAEE and worsening insulin resistance, possibly via shared molecular pathways.
Ämnesord och genrebeteckningar
- Adiposity
- Cohort Studies
- Diabetes Mellitus; Type 2/*etiology/metabolism/physiopathology
- Energy Metabolism
- Female
- Follow-Up Studies
- Heart Rate
- Humans
- Insulin/blood
- Insulin Resistance
- Leptin/*blood
- Linear Models
- Male
- Middle Aged
- Models; Biological
- Motor Activity
- Prospective Studies
- Time Factors
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Loos, R J F (författare)
- Brage, S (författare)
- O'Rahilly, S (författare)
- Wareham, N J (författare)
- Ekelund, U (författare)
- Umeå universitetMedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:J Appl Physiol: American Physiological Society102:5, s. 1921-68750-7587
- Ingår i:Journal of Applied Physiology: American Physiological Society102:5, s. 1921-61522-1601
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- Franks, Paul
- Loos, R J F
- Brage, S
- O'Rahilly, S
- Wareham, N J
- Ekelund, U
- Artiklar i publikationen
- J Appl Physiol
- Journal of Appli ...
- Av lärosätet
- Umeå universitet
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