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Genetic architectur...
Genetic architectures of proximal and distal colorectal cancer are partly distinct
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- Huyghe, Jeroen R (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Harrison, Tabitha A (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Bien, Stephanie A (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hampel, Heather (author)
- Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
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- Figueiredo, Jane C (author)
- Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- Schmit, Stephanie L (author)
- Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States
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- Conti, David V (author)
- Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
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- Chen, Sai (author)
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
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- Qu, Conghui (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Lin, Yi (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Barfield, Richard (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Baron, John A (author)
- Department of Medicine, University of North Carolina School of Medicine, NC, Chapel Hill, United States
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- Cross, Amanda J (author)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Diergaarde, Brenda (author)
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Upmc Hillman Cancer Center, PA, Pittsburgh, United States
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- Duggan, David (author)
- Translational Genomics Research Institute-An Affiliate of City of Hope, AZ, Phoenix, United States
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- Harlid, Sophia, 1978- (author)
- Umeå universitet,Onkologi
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- Imaz, Liher (author)
- Public Health Division of Gipuzkoa, Health Department of Basque Country, San Sebastian, Spain
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- Kang, Hyun Min (author)
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
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- Levine, David M (author)
- Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Perduca, Vittorio (author)
- Laboratoire de Mathématiques Appliqueés MAP5 (UMR Cnrs 8145), Université Paris Descartes, Paris, France; Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France
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- Perez-Cornago, Aurora (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Sakoda, Lori C (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Schumacher, Fredrick R (author)
- Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
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- Slattery, Martha L (author)
- Department of Internal Medicine, University of Utah Health, UT, Salt Lake City, United States
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- Toland, Amanda E (author)
- Departments of Cancer Biology and Genetics and Internal Medicine, The Ohio State University, OH, Columbus, United States
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- Van Duijnhoven, Fränzel J B (author)
- Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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- Agudo, Antonio (author)
- Karolinska Institutet
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- Albanes, Demetrius (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Alonso, M Henar (author)
- Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Ciber Epidemiologiá y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Anderson, Kristin (author)
- Division of Epidemiology and Community Health, University of Minnesota, MN, Minneapolis, United States
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- Arnau-Collell, Coral (author)
- Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Arndt, Volker (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany
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- Banbury, Barbara L (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Bassik, Michael C (author)
- Department of Genetics, Stanford University, California, Stanford, United States
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- Berndt, Sonja I (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Bézieau, Stéphane (author)
- Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
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- Bishop, D Timothy (author)
- Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
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- Boehm, Juergen (author)
- Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Utah, Salt Lake City, United States
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- Boeing, Heiner (author)
- Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany
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- Boutron-Ruault, Marie-Christine (author)
- Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
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- Brenner, Hermann (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Centre (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Brezina, Stefanie (author)
- Institute of Cancer Research, Department of Medicine i, Medical University of Vienna, Vienna, Austria
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- Buch, Stephan (author)
- Department of Medicine i, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
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- Buchanan, Daniel D (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Clinical Pathology, the University of Melbourne, VIC, Melbourne, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Melbourne, Australia
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- Burnett-Hartman, Andrea (author)
- Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
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- Caan, Bette J (author)
- Division of Research, Kaiser Permanente Medical Care Program, CA, Oakland, United States
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- Campbell, Peter T (author)
- Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States
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- Carr, Prudence R (author)
- Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
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- Castells, Antoni (author)
- Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Castellví-Bel, Sergi (author)
- Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Chan, Andrew T (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Chang-Claude, Jenny (author)
- Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
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- Chanock, Stephen J (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Curtis, Keith R (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- De La Chapelle, Albert (author)
- Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, OH, Columbus, United States
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- Easton, Douglas F (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- English, Dallas R (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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- Feskens, Edith J M (author)
- Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
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- Gala, Manish (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Gallinger, Steven J (author)
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Gauderman, W James (author)
- Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
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- Giles, Graham G (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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- Goodman, Phyllis J (author)
- Swog Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Grady, William M (author)
- Clinical Research Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Medicine, University of Washington School of Medicine, WA, Seattle, United States
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- Grove, John S (author)
- University of Hawai'i Cancer Center, HI, Honolulu, United States
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- Gsur, Andrea (author)
- Institute of Cancer Research, Department of Medicine i, Medical University of Vienna, Vienna, Austria
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- Gunter, Marc J (author)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Haile, Robert W (author)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- Hampe, Jochen (author)
- Department of Medicine i, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
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- Hoffmeister, Michael (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany
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- Hopper, John L (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
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- Hsu, Wan-Ling (author)
- Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Huang, Wen-Yi (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Hudson, Thomas J (author)
- Ontario Institute for Cancer Research, ON, Toronto, Canada
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- Jenab, Mazda (author)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Jenkins, Mark A (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Joshi, Amit D (author)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Keku, Temitope O (author)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
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- Kooperberg, Charles (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Kühn, Tilman (author)
- Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
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- Küry, Sébastien (author)
- Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
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- Le Marchand, Loic (author)
- University of Hawai'i Cancer Center, HI, Honolulu, United States
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- Lejbkowicz, Flavio (author)
- The Clalit Health Services, Personalized Genomic Service, Carmel Medical Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Li, Christopher I (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Li, Li (author)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Lieb, Wolfgang (author)
- Institute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany
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- Lindblom, Annika (author)
- Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Lindor, Noralane M (author)
- Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States
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- Männistö, Satu (author)
- Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
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- Markowitz, Sanford D (author)
- Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, OH, Cleveland, United States
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- Milne, Roger L (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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- Moreno, Lorena (author)
- Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
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- Murphy, Neil (author)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Nassir, Rami (author)
- Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
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- Offit, Kenneth (author)
- Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States
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- Ogino, Shuji (author)
- Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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- Panico, Salvatore (author)
- Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy
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- Parfrey, Patrick S (author)
- Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, St. John's, Canada
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- Pearlman, Rachel (author)
- Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
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- Pharoah, Paul D P (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Phipps, Amanda I (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Platz, Elizabeth A (author)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States
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- Potter, John D (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Prentice, Ross L (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Qi, Lihong (author)
- Department of Public Health Sciences, School of Medicine, University of California Davis, CA, Davis, United States
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- Raskin, Leon (author)
- Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States
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- Rennert, Gad (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
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- Rennert, Hedy S (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
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- Riboli, Elio (author)
- School of Public Health, Imperial College London, London, United Kingdom
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- Schafmayer, Clemens (author)
- Department of General Surgery, University Hospital Rostock, Rostock, Germany
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- Schoen, Robert E (author)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Seminara, Daniela (author)
- Division of Cancer Control and Population Sciences, National Cancer Institute, MD, Bethesda, United States
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- Song, Mingyang (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Su, Yu-Ru (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Tangen, Catherine M (author)
- Swog Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Thibodeau, Stephen N (author)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, MayoClinic, MN, Rochester, United States
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- Thomas, Duncan C (author)
- Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens, Greece; Who Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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- Ulrich, Cornelia M (author)
- Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Utah, Salt Lake City, United States
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- Visvanathan, Kala (author)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States
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- Vodicka, Pavel (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Vodickova, Ludmila (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Vymetalkova, Veronika (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Weigl, Korbinian (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, University of Heidelberg, Heidelberg, Germany
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- Weinstein, Stephanie J (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- White, Emily (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Wolk, Alicja (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Woods, Michael O (author)
- Discipline of Genetics, Memorial University of Newfoundland, Newfoundland, St. John's, Canada
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- Wu, Anna H (author)
- Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
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- Abecasis, Goncalo R (author)
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
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- Nickerson, Deborah A (author)
- Department of Genome Sciences, University of Washington, WA, Seattle, United States
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- Scacheri, Peter C (author)
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, OH, Cleveland, United States
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- Kundaje, Anshul (author)
- Department of Genetics, Stanford University, California, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Casey, Graham (author)
- Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
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- Gruber, Stephen B (author)
- Department of Preventive Medicine, Usc Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, CA, Los Angeles, United States; City of Hope National Medical Center, CA, Duarte, United States
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- Hsu, Li (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Moreno, Victor (author)
- Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Ciber Epidemiologiá y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Hayes, Richard B (author)
- Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States
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- Newcomb, Polly A (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Peters, Ulrike (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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(creator_code:org_t)
- 2021-02-25
- 2021
- English.
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In: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 70:7, s. 1325-1334
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Abstract
Subject headings
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- Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.Design: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling.Results: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer.Conclusion: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cancer genetics
- cancer susceptibility
- colon carcinogenesis
- colorectal cancer
- genetic polymorphisms
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- ref (subject category)
- art (subject category)
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Burnett-Hartman, ...
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Caan, Bette J
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Campbell, Peter ...
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Carr, Prudence R
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Castells, Antoni
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Castellví-Bel, S ...
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Chan, Andrew T
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Chang-Claude, Je ...
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Chanock, Stephen ...
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Curtis, Keith R
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De La Chapelle, ...
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Easton, Douglas ...
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English, Dallas ...
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Feskens, Edith J ...
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Gala, Manish
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Gallinger, Steve ...
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Gauderman, W Jam ...
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Giles, Graham G
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Goodman, Phyllis ...
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Grady, William M
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Grove, John S
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Gsur, Andrea
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Gunter, Marc J
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Haile, Robert W
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Hampe, Jochen
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Hoffmeister, Mic ...
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Hopper, John L
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Hsu, Wan-Ling
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Huang, Wen-Yi
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Hudson, Thomas J
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Jenab, Mazda
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Jenkins, Mark A
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Joshi, Amit D
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Keku, Temitope O
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Kooperberg, Char ...
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Kühn, Tilman
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Küry, Sébastien
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Le Marchand, Loi ...
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Lejbkowicz, Flav ...
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Li, Christopher ...
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Li, Li
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Lieb, Wolfgang
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Lindblom, Annika
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Lindor, Noralane ...
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Männistö, Satu
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Markowitz, Sanfo ...
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Milne, Roger L
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Moreno, Lorena
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Murphy, Neil
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Nassir, Rami
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Offit, Kenneth
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Ogino, Shuji
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Panico, Salvator ...
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Parfrey, Patrick ...
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Pearlman, Rachel
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Pharoah, Paul D ...
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Phipps, Amanda I
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Platz, Elizabeth ...
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Potter, John D
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Prentice, Ross L
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Qi, Lihong
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Raskin, Leon
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Rennert, Gad
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Rennert, Hedy S
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Riboli, Elio
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Schafmayer, Clem ...
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Schoen, Robert E
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Seminara, Daniel ...
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Song, Mingyang
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Su, Yu-Ru
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Tangen, Catherin ...
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Thibodeau, Steph ...
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Thomas, Duncan C
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Trichopoulou, An ...
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Ulrich, Cornelia ...
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Visvanathan, Kal ...
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Vodicka, Pavel
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Vodickova, Ludmi ...
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Vymetalkova, Ver ...
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Weigl, Korbinian
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Weinstein, Steph ...
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White, Emily
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Wolk, Alicja
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Woods, Michael O
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Wu, Anna H
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Abecasis, Goncal ...
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Nickerson, Debor ...
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Scacheri, Peter ...
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Kundaje, Anshul
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Casey, Graham
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Gruber, Stephen ...
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Hsu, Li
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Moreno, Victor
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Hayes, Richard B
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Newcomb, Polly A
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Peters, Ulrike
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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- By the university
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Umeå University
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Uppsala University
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Karolinska Institutet