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BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae
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- del Peso Santos, Teresa (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Alvarez, Laura (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Sit, Brandon (author)
- Howard Hughes Medical Institute, Brigham and Women’s Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, MA, Boston, United States
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- (creator_code:org_t)
- eLife Sciences Publications Ltd. 2021
- 2021
- English.
- In: eLIFE. - : eLife Sciences Publications Ltd.. - 2050-084X. ; 10
- Journal article (peer-reviewed)
Abstract
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- Adaptation to shifting temperatures is crucial for the survival of the bacterial pathogen Vibrio cholerae. Here, we show that colony rugosity, a biofilm-associated phenotype, is regulated by temperature in V. cholerae strains that naturally lack the master biofilm transcriptional regulator HapR. Using transposon-insertion mutagenesis, we found the V. cholerae ortholog of BipA, a conserved ribosome-associated GTPase, is critical for this temperature-dependent phenomenon. Proteomic analyses revealed that loss of BipA alters the synthesis of >300 proteins in V. cholerae at 22˚C, increasing the production of biofilm-related proteins including the key transcriptional activators VpsR and VpsT, as well as proteins important for diverse cellular processes. At low temperatures, BipA protein levels increase and are required for optimal ribosome assembly in V. cholerae, suggesting that control of BipA abundance is a mechanism by which bacteria can remodel their proteomes. Our study reveals a remarkable new facet of V. cholerae’s complex biofilm regulatory network.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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- Warr, Alyson R.
- Bala, Anju
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- Fredrick, Kurt
- Cava, Felipe
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