Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia: Results from the Betula Cohort in Northern Sweden

Oudin Åström, DanielUmeå University,Umeå universitet,Avdelningen för hållbar hälsa (författare)

Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia : Results from the Betula Cohort in Northern Sweden

Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1μg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Air pollution
Alzheimer’s disease
PM2.5
dementia
particulate air pollution
Air pollution
Alzheimer's disease
dementia
particulate air pollution
PM

Adolfsson, RolfUmeå University,Umeå universitet,Psykiatri(Swepub:umu)road0001 (författare)
Segersson, DavidSwedish Meteorological and Hydrological Institute, Norrköping, Sweden. (författare)
Forsberg, BertilUmeå University,Umeå universitet,Avdelningen för hållbar hälsa,Arcum(Swepub:umu)befo0001 (författare)
Oudin, AnnaUmeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Environment, Society and Health, Occupational and Environmental Medicine, Department for Laboratory Medicine, Lund University, Lund, Sweden.,Arcum,Planetär hälsa,Forskargrupper vid Lunds universitet,Planetary Health,Lund University Research Groups(Swepub:lu)med-aao (författare)
Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

Ingår i:Journal of Alzheimer's Disease: IOS Press81:1, s. 83-851387-28771875-8908

Av författaren/redakt...: Oudin Åström, Da ...; Adolfsson, Rolf; Segersson, David; Forsberg, Bertil; Oudin, Anna

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