Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.

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Meng, Xia (author)

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality : multilocation analysis in 398 cities.

Article/chapterEnglish2021

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2021-03-24
BMJ Publishing Group Ltd,2021
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LIBRIS-ID:oai:DiVA.org:umu-181867
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181867URI
https://doi.org/10.1136/bmj.n534DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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OBJECTIVE: To evaluate the short term associations between nitrogen dioxide (NO2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol.DESIGN: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis.SETTING: 398 cities in 22 low to high income countries/regions.MAIN OUTCOME MEASURES: Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018.RESULTS: On average, a 10 μg/m3 increase in NO2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM10 and PM2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities.CONCLUSIONS: This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO2.

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Liu, Cong (author)
Chen, Renjie (author)
Sera, Francesco (author)
Vicedo-Cabrera, Ana Maria (author)
Milojevic, Ai (author)
Guo, Yuming (author)
Tong, Shilu (author)
Coelho, Micheline de Sousa Zanotti Stagliorio (author)
Saldiva, Paulo Hilario Nascimento (author)
Lavigne, Eric (author)
Correa, Patricia Matus (author)
Ortega, Nicolas Valdes (author)
Osorio Garcia, Samuel (author)
Kyselý, Jan (author)
Urban, Aleš (author)
Orru, HansUmeå universitet,Avdelningen för hållbar hälsa,Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia(Swepub:umu)haor0004 (author)
Maasikmets, Marek (author)
Jaakkola, Jouni J. K. (author)
Ryti, Niilo (author)
Huber, Veronika (author)
Schneider, Alexandra (author)
Katsouyanni, Klea (author)
Analitis, Antonis (author)
Hashizume, Masahiro (author)
Honda, Yasushi (author)
Ng, Chris Fook Sheng (author)
Nunes, Baltazar (author)
Teixeira, João Paulo (author)
Holobaca, Iulian Horia (author)
Fratianni, Simona (author)
Kim, Ho (author)
Tobias, Aurelio (author)
Íñiguez, Carmen (author)
Forsberg, BertilUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)befo0001 (author)
Åström, Christofer,1983-Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)chas0002 (author)
Ragettli, Martina S. (author)
Guo, Yue-Liang Leon (author)
Pan, Shih-Chun (author)
Li, Shanshan (author)
Bell, Michelle L. (author)
Zanobetti, Antonella (author)
Schwartz, Joel (author)
Wu, Tangchun (author)
Gasparrini, Antonio (author)
Kan, Haidong (author)
Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

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By the author/editor: Meng, Xia; Liu, Cong; Chen, Renjie; Sera, Francesco; Vicedo-Cabrera, ...; Milojevic, Ai; show more...; Guo, Yuming; Tong, Shilu; Coelho, Michelin ...; Saldiva, Paulo H ...; Lavigne, Eric; Correa, Patricia ...; Ortega, Nicolas ...; Osorio Garcia, S ...; Kyselý, Jan; Urban, Aleš; Orru, Hans; Maasikmets, Mare ...; Jaakkola, Jouni ...; Ryti, Niilo; Huber, Veronika; Schneider, Alexa ...; Katsouyanni, Kle ...; Analitis, Antoni ...; Hashizume, Masah ...; Honda, Yasushi; Ng, Chris Fook S ...; Nunes, Baltazar; Teixeira, João P ...; Holobaca, Iulian ...; Fratianni, Simon ...; Kim, Ho; Tobias, Aurelio; Íñiguez, Carmen; Forsberg, Bertil; Åström, Christof ...; Ragettli, Martin ...; Guo, Yue-Liang L ...; Pan, Shih-Chun; Li, Shanshan; Bell, Michelle L ...; Zanobetti, Anton ...; Schwartz, Joel; Wu, Tangchun; Gasparrini, Anto ...; Kan, Haidong; show less...

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