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Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen-Friedenreich conjugate

Wu, Xuanjun (författare)
National Glycoengineering Research Center, Shandong University, Shandong, Qingdao, China; Department of Chemistry, Michigan State University, MI, East Lansing, United States
McFall-Boegeman, Hunter (författare)
Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
Rashidijahanabad, Zahra (författare)
Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
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Liu, Kunli (författare)
Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
Pett, Christian (författare)
Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
Yu, Jin (författare)
Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
Schorlemer, Manuel (författare)
Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
Ramadan, Sherif (författare)
Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States; Chemistry Department, Faculty of Science, Benha University, Qaliobiya, Benha, Egypt
Behren, Sandra (författare)
Umeå universitet,Kemiska institutionen
Westerlind, Ulrika (författare)
Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
Huang, Xuefei (författare)
Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States; Department of Biomedical Engineering, Michigan State University, MI, East Lansing, United States
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 (creator_code:org_t)
2021
2021
Engelska.
Ingår i: Organic and biomolecular chemistry. - : Royal Society of Chemistry. - 1477-0520 .- 1477-0539. ; 19:11, s. 2448-2455
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • MUC1 glycopeptides are attractive antigens for anti-cancer vaccine development. One potential drawback in using the native MUC1 glycopeptide for vaccine design is the instability of theO-glycosyl linkage between the glycan and the peptide backbone to glycosidase. To overcome this challenge, a MUC1 glycopeptide mimic has been synthesized with the galactose-galactosamine disaccharide linked with threonine (Thomsen-Friedenreich or Tf antigen) through an unnatural β-glycosyl bond. The resulting MUC1-β-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural α-Tf linkage. The MUC1-β-Tf was subsequently conjugated with a powerful carrier bacteriophage Qβ. The conjugate induced high levels of IgG antibodies in clinically relevant human MUC1 transgenic mice, which cross-recognized not only the natural MUC1-α-Tf glycopeptide but also MUC1 expressing tumor cells, supporting the notion that a simple switch of the stereochemistry of the glycan/peptide linkage can be a strategy for anti-cancer vaccine epitope design for glycopeptides.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

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