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Prevalent diabetes ...
Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population : meta-analysis of individual participant data from cohorts of the CHANCES consortium
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- Amadou, Amina (författare)
- International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France; Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
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- Tsilidis, Konstantinos K. (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens, Greece
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- Boffetta, Paolo (författare)
- Stony Brook Cancer Center, Stony Brook University, NY, Stony Brook, United States; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Mokoroa, Olatz (författare)
- Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain
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- Wilsgaard, Tom (författare)
- Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Kee, Frank (författare)
- Institute for Health Sciences Risk and Inequality, Centre for Public Health, Belfast, United Kingdom
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- Schöttker, Ben (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Ordóñez-Mena, José M. (författare)
- Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Woodstock Road, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
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- Männistö, Satu (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Söderberg, Stefan (författare)
- Umeå universitet,Avdelningen för medicin
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- Vermeulen, Roel C. H. (författare)
- Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
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- Quirós, J. Ramón (författare)
- Public Health Directorate, Asturias, Spain
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- Liao, Linda M. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Sinha, Rashmi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Kuulasmaa, Kari (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
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(creator_code:org_t)
- 2021-03-26
- 2021
- Engelska.
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Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 124:11, s. 1882-1890
- Relaterad länk:
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https://ora.ox.ac.uk...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.Results: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity.Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Amadou, Amina
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Freisling, Heinz
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Jenab, Mazda
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Tsilidis, Konsta ...
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Trichopoulou, An ...
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Boffetta, Paolo
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visa fler...
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van Guelpen, Bet ...
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Mokoroa, Olatz
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Wilsgaard, Tom
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Kee, Frank
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Schöttker, Ben
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Ordóñez-Mena, Jo ...
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Männistö, Satu
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Söderberg, Stefa ...
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Vermeulen, Roel ...
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Quirós, J. Ramón
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Liao, Linda M.
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Sinha, Rashmi
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Kuulasmaa, Kari
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Brenner, Hermann
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Romieu, Isabelle
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