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Ambient carbon mono...
Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities
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- Chen, Kai (author)
- Department of Environmental Health Sciences, Yale School of Public Health, CT, New Haven, United States
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- Breitner, Susanne (author)
- Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
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- Wolf, Kathrin (author)
- Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
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- Stafoggia, Massimo (author)
- Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
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- Sera, Francesco (author)
- Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom; Department of Statistics, Computer Science and Applications “G. Parenti”, University of Florence, Florence, Italy
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- Vicedo-Cabrera, Ana M. (author)
- Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Oeschger Center for Climate Change Research, University of Bern, Bern, Switzerland
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- Guo, Yuming (author)
- Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, VIC, Melbourne, Australia
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- Tong, Shilu (author)
- Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China; School of Public Health and Social Work, Queensland University of Technology, QLD, Brisbane, Australia; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
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- Lavigne, Eric (author)
- Air Health Science Division, Health Canada, ON, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, ON, Ottawa, Canada
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- Matus, Patricia (author)
- Department of Public Health, Universidad de los Andes, Santiago, Chile
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- Valdés, Nicolás (author)
- Faculty of Nursing and Midwifery, Universidad de los Andes, Santiago, Chile
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- Kan, Haidong (author)
- School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, China
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- Jaakkola, Jouni J. K. (author)
- Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Finnish Meteorological Institute, Helsinki, Finland
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- Ryti, Niilo R. I. (author)
- Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland
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- Huber, Veronika (author)
- Department of Physical, Chemical and Natural Systems, Universidad Pablo de Olavide, Seville, Spain; Potsdam Institute for Climate Impact Research, Potsdam, Germany
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- Scortichini, Matteo (author)
- Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
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- Hashizume, Masahiro (author)
- Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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- Honda, Yasushi (author)
- Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan
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- Nunes, Baltazar (author)
- Department of Epidemiology, Instituto Nacional de Saúde Dr Ricardo Jorge, Lisbon, Portugal; Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Lisbon, Portugal
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- Madureira, Joana (author)
- Department of Enviromental Health, Instituto Nacional de Saúde Dr Ricardo Jorge, Porto, Portugal; EPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal
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- Holobâcă, Iulian Horia (author)
- Faculty of Geography, Babes-Bolay University, Cluj-Napoca, Romania
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- Fratianni, Simona (author)
- Department of Earth Sciences, University of Torino, Turin, Italy
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- Kim, Ho (author)
- Graduate School of Public Health, Seoul National University, Seoul, South Korea
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- Lee, Whanhee (author)
- Graduate School of Public Health, Seoul National University, Seoul, South Korea
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- Tobias, Aurelio (author)
- Institute of Environmental Assessment and Water Research, Spanish Council for Scientific Research, Barcelona, Spain; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan
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- Íñiguez, Carmen (author)
- Department of Statistics and Computational Research, University of Valencia, Valencia, Spain; , Ciberesp, Madrid, Spain
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- Forsberg, Bertil, professor, 1956- (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Åström, Christofer, 1983- (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Ragettli, Martina S. (author)
- Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland
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- Guo, Yue-Liang Leon (author)
- Environmental and Occupational Medicine, National Taiwan University and NTU Hospital, Taipei, Taiwan; National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan
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- Chen, Bing-Yu (author)
- National Institute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan
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- Li, Shanshan (author)
- Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, VIC, Melbourne, Australia
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- Milojevic, Ai (author)
- Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom
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- Zanobetti, Antonella (author)
- Department of Environmental Health, Harvard T H Chan School of Public Health, MA, Boston, United States
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- Schwartz, Joel (author)
- Department of Environmental Health, Harvard T H Chan School of Public Health, MA, Boston, United States
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- Bell, Michelle L. (author)
- School of the Environment, Yale University, CT, New Haven, United States
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- Gasparrini, Antonio (author)
- Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
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- Schneider, Alexandra (author)
- Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: The Lancet Planetary Health. - 2542-5196. ; 5:4, s. e191-e199
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Abstract
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- Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between ambient CO and daily mortality, even at levels well below current air quality guidelines. Further studies are warranted to disentangle its independent effect from other traffic-related pollutants. Funding: EU Horizon 2020, UK Medical Research Council, and Natural Environment Research Council.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Chen, Kai
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Breitner, Susann ...
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Wolf, Kathrin
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Stafoggia, Massi ...
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Sera, Francesco
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Vicedo-Cabrera, ...
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show more...
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Guo, Yuming
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Tong, Shilu
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Lavigne, Eric
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Matus, Patricia
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Valdés, Nicolás
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Kan, Haidong
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Jaakkola, Jouni ...
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Ryti, Niilo R. I ...
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Huber, Veronika
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Scortichini, Mat ...
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Hashizume, Masah ...
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Honda, Yasushi
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Nunes, Baltazar
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Madureira, Joana
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Holobâcă, Iulian ...
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Fratianni, Simon ...
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Kim, Ho
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Lee, Whanhee
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Tobias, Aurelio
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Íñiguez, Carmen
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Forsberg, Bertil ...
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Åström, Christof ...
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Ragettli, Martin ...
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Guo, Yue-Liang L ...
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Chen, Bing-Yu
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Li, Shanshan
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Milojevic, Ai
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Zanobetti, Anton ...
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Schwartz, Joel
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Bell, Michelle L ...
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Gasparrini, Anto ...
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Schneider, Alexa ...
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