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Plasma Amyloid-β in...
Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae
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- Lopatko Lindman, Karin (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umeå, Sweden.
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- Weidung, Bodil (author)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umeå, Sweden.
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- Olsson, Jan (author)
- Umeå universitet,Avdelningen för virologi,Umeå Univ, Dept Clin Microbiol, Virol, Umeå, Sweden.
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- Josefsson, Maria, 1979- (author)
- Umeå universitet,Statistik,Enheten för demografi och åldrandeforskning (CEDAR),Umeå Univ, Ctr Demog & Ageing Res, Umeå, Sweden.
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- Johansson, Anders, 1955- (author)
- Umeå universitet,Institutionen för odontologi,Avdelningen för hållbar hälsa,Umeå Univ, Dept Odontol, Umeå, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Eriksson, Sture (author)
- Umeå universitet,Geriatrik,Avdelningen för hållbar hälsa,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umeå, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Avdelningen för virologi,Umeå Univ, Dept Clin Microbiol, Virol, Umeå, Sweden.
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Geriatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med, Umeå, Sweden.
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- English.
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In: Journal of Alzheimer's Disease Reports. - : IOS Press. - 2542-4823. ; 5:1, s. 229-235
- Related links:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties.Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae.Methods: Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases.Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls.Conclusion: Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer’s disease
- amyloid-β peptides
- Chlamydophila pneumoniae
- cytomegalovirus
- dementia
- Herpes simplex
- nested case-control study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lopatko Lindman, ...
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Weidung, Bodil
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Olsson, Jan
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Josefsson, Maria ...
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Johansson, Ander ...
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Eriksson, Sture
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Hallmans, Göran, ...
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Elgh, Fredrik, 1 ...
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Lövheim, Hugo, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Umeå University
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Uppsala University