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Do environmental ri...
Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences?
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- Cosgrave, Jan (author)
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom
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- Purple, Ross J. (author)
- Department of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom
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- Haines, Ross (author)
- Department of Statistics, University of Oxford, South Parks Road, Oxford, United Kingdom
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- Porcheret, Kate (author)
- Norwegian Centre for Violence & Traumatic Stress Studies, University of Oslo, Oslo, Norway
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- van Heugten-van der Kloet, Dalena (author)
- Department of Clinical Psychological Science, Maastricht University, Maastricht University, Maastricht, Netherlands
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- Johns, Louise (author)
- Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, United Kingdom
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- Alexander, Iona (author)
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
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- Goodwin, Guy M. (author)
- Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, United Kingdom
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- Foster, Russell G. (author)
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
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- Wulff, Katharina (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Diagnostisk radiologi
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(creator_code:org_t)
- 2021-04-19
- 2021
- English.
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In: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 11:1
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Psychotic experiences (PE) are associated with poorer functioning, higher distress and the onset of serious mental illness. Environmental exposures (e.g. childhood abuse) are associated with the development of PE. However, which specific exposures convey risk for each type or dimension of PE has rarely been explored. The Oxford Wellbeing Life and Sleep (OWLS) survey includes 22 environmental risk factors for psychosis and was designed to examine how environmental risks are associated with specific dimensions of PE. Multivariate logistic regression models were fit using these risk factors to predict six dimensions of PE (perceptual abnormalities, persecutory ideation, bizarre ideas, cognitive disorganisation, delusional mood and negative symptoms). Models were built using only 70% of the data, and then fit to the remaining data to assess their generalisability and quality. 1789 (27.2% men; mean age = 27.6; SD = 10.9) survey responses were analysed. The risk factors predictive of the most PE were anxiety, social withdrawal during childhood and trauma. Cannabis and depression predicted three dimensions with both predicting bizarre ideas and persecutory ideation. Psychological abuse and sleep quality each predicted two dimensions (persecutory ideation and delusional mood). Risk factors predicting one PE dimension were age (predicting cognitive disorganisation), physical abuse (bizarre ideas), bullying and gender (persecutory ideation); and circadian phase (delusional mood). These results lend support for a continuum of psychosis, suggesting environmental risks for psychotic disorders also increase the risk of assorted dimensions of PE. Furthermore, it advocates the use of dimensional approaches when examining environmental exposures for PE given that environmental risks distribute differently across dimensions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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