Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

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Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

Kliemann, Nathalie (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Viallon, Vivian (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Murphy, Neil (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

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Beeken, Rebecca J. (författare): Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom; Department of Behavioural Science and Health, University College London, London, United Kingdom,Leeds School of Medicine

Rothwell, Joseph A. (författare): Health Across Generations team, Centre for Research in Epidemiology and Population Health (CESP), INSERM U1018, Villejuif, France; Gustave Roussy, Villejuif, France,Institut Gustave Roussy

Rinaldi, Sabina (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Assi, Nada (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

van Roekel, Eline H. (författare): Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands

Schmidt, Julie A. (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

Borch, Kristin Benjaminsen (författare): Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway

Agnoli, Claudia (författare): Epidemiology and Prevention Unit. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Rosendahl, Ann H. (författare): Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital

Sartor, Hanna (författare): Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments

Huerta, José María (författare): CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)

Tjønneland, Anne (författare): Danish Cancer Society Research Center, Copenhagen, Denmark

Halkjær, Jytte (författare): Danish Cancer Society Research Center, Copenhagen, Denmark

Bueno-de-Mesquita, Bas (författare): Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)

Gicquiau, Audrey (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Achaintre, David (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Aleksandrova, Krasimira (författare): Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

Schulze, Matthias B. (författare): Institute of Nutritional Science, University of Potsdam, Potsdam, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

Heath, Alicia K. (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Tsilidis, Konstantinos K. (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

Masala, Giovanna (författare): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy

Panico, Salvatore (författare): Dipartimento di Medicin Clinica e Chirurgia, Frederico II Univeristy, Naples, Italy

Kaaks, Rudolf (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Fortner, Renée T. (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

van Guelpen, Bethany (författare): Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Scalbert, Augustin (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Keun, Hector C. (författare): Cancer Metabolism and Systems Toxicology Group, Division of Cancer, Department of Surgery and Cancer, Imperial College, London, United Kingdom

Travis, Ruth C. (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

Jenab, Mazda (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Johansson, Mattias (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Ferrari, Pietro (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

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2021-04-30
2021
Engelska.
Ingår i: BMC Medicine. - : BioMed Central. - 1741-7015. ; 19:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://bmcmedicine....; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.Methods: Targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and 17 individuals from a single-arm pilot weight loss intervention (Intercept) were used in this analysis. Metabolic signatures of body size were first determined in discovery (N = 3029) and replication (N = 1297) sets among EPIC participants by testing the associations between 129 metabolites and body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) using linear regression models followed by partial least squares analyses. Conditional logistic regression models assessed the associations between the metabolic signatures with endometrial (N = 635 cases and 648 controls) and colorectal (N = 423 cases and 423 controls) cancer risk using nested case-control studies in EPIC. Pearson correlation between changes in the metabolic signatures and weight loss was tested among Intercept participants.Results: After adjustment for multiple comparisons, greater BMI, WC, and WHR were associated with higher levels of valine, isoleucine, glutamate, PC aa C38:3, and PC aa C38:4 and with lower levels of asparagine, glutamine, glycine, serine, lysoPC C17:0, lysoPC C18:1, lysoPC C18:2, PC aa C42:0, PC ae C34:3, PC ae C40:5, and PC ae C42:5. The metabolic signature of BMI (OR1-sd 1.50, 95% CI 1.30–1.74), WC (OR1-sd 1.46, 95% CI 1.27–1.69), and WHR (OR1-sd 1.54, 95% CI 1.33–1.79) were each associated with endometrial cancer risk. Risk of colorectal cancer was positively associated with the metabolic signature of WHR (OR1-sd: 1.26, 95% CI 1.07–1.49). In the Intercept study, a positive correlation was observed between weight loss and changes in the metabolic signatures of BMI (r = 0.5, 95% CI 0.06–0.94, p = 0.03), WC (r = 0.5, 95% CI 0.05–0.94, p = 0.03), and WHR (r = 0.6, 95% CI 0.32–0.87, p = 0.01).Conclusions: Obesity is associated with a distinct metabolic signature comprising changes in levels of specific amino acids and lipids which is positively associated with both colorectal and endometrial cancer and is potentially reversible following weight loss.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

Cancer
Metabolomics
Obesity
Weight loss
Cancer
Metabolomics
Obesity
Weight loss

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