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(WFRF:(Bueno de Mesquita H. Bas)) pers:(Sanchez Maria Jose)
 

Sökning: (WFRF:(Bueno de Mesquita H. Bas)) pers:(Sanchez Maria Jose) > (2020-2022) > Red blood cell fatt...

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC)

Linseisen, Jakob (författare)
Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; Clinical Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany; Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T Augsburg, Neus€asser Straße 47, Augsburg, Germany
Grundmann, Nina (författare)
Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; Clinical Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
Zoller, Dorothee (författare)
Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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Kuhn, Tilman (författare)
German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Jansen, Eugene H.J.M. (författare)
Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Chajes, Veronique (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Fedirko, Veronika (författare)
Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, GA, Atlanta, United States
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Dahm, Christina C. (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Overvad, Kim (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
Boutron-Ruault, Marie-Christine (författare)
Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France
Rothwell, Joseph A. (författare)
Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France
Severi, Gianluca (författare)
Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy
Kaaks, Rudolf (författare)
German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Schulze, Matthias B. (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Aleksandrova, Krasimira (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
de Marco, Laura (författare)
Cancer Epidemiology Unit, A.O.U. Citta della Salute e della Scienza Hospital and CPO Piemonte, Turin, Italy
Bueno-De-Mesquita, Bas (författare)
Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Vermeulen, Roel (författare)
Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
Gram, Inger T. (författare)
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway
Skeie, Guri (författare)
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway
Chirlaque, María-Dolores (författare)
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
Ardanaz, Eva (författare)
Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Agudo, Antonio (författare)
Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Sánchez, Maria-Jose (författare)
Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Publica (EASP), Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Amiano, Pilar (författare)
Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain
Wennberg, Maria, 1974- (författare)
Umeå universitet,Näringsforskning,Avdelningen för hållbar hälsa
Bodén, Stina (författare)
Umeå universitet,Onkologi
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, Oxford, United Kingdom
Aglago, Elom K. (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Gunter, Marc J. (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Jenab, Mazda (författare)
International Agency for Research on Cancer (IARC-WHO), Lyon, France
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Nieters, Alexandra (författare)
Institute of Immunodeficiency, Medical Faculty, University Hospital Freiburg, Freiburg, Germany
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 (creator_code:org_t)
American Association for Cancer Research (AACR), 2021
2021
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 30:5, s. 874-885
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models.Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk.Impact: These findings add to the evidence on colorectal cancer prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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